Results 31 to 40 of about 4,129,225 (254)

Emulating climate extreme indices

open access: yesEnvironmental Research Letters, 2020
We use simple pattern scaling and time-shift to emulate changes in a set of climate extreme indices under future scenarios, and we evaluate the emulators’ accuracy.
C Tebaldi   +3 more
doaj   +1 more source

A bill for the Delta state internal revenue service. [PDF]

open access: yes, 2020
A law to repeal the Delta state internal revenue consolidation law 2009 and enact the Delta state internal revenue service, establish the internal revenue service board and for other matters connected there with be it enacted by the Delta state house of ...
DELTA state internal revenue service.
core  

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Attribution of the July–August 2013 heat event in Central and Eastern China to anthropogenic greenhouse gas emissions

open access: yesEnvironmental Research Letters, 2017
In the midsummer of 2013, Central and Eastern China (CEC) was hit by an extraordinary heat event, with the region experiencing the warmest July–August on record.
Shuangmei Ma   +4 more
doaj   +1 more source

Low-frequency internal oceanic variability under seasonal forcing

open access: yes, 1992
A series of numerical experiments are conducted using the Bryan-Cox ocean general circulation model to investigate the potential existence of low-frequency variability of the thermohaline circulation under seasonal forcing. Experiments are performed with
Myers, Paul G., Weaver, Andrew J.
core   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

open access: yesFEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg   +14 more
wiley   +1 more source

Seasonal Variability Of Mode-1 And Mode-2 Internal Solitary Waves Off The Amazon Shelf Observed From Modis/Terra Sunglint Images

open access: yes, 2023
This study focuses on the Amazon ISWs occurrence, their velocity/wavelength, and variability at seasonal cycles. The analysis is based on a data set composed of 71 MODIS/TERRA images, where more than 250 internal solitary wave (ISW) signatures were ...
Koch-Larrouy, Ariane   +7 more
core  

Anthropogenic climate change drives non-stationary phytoplankton internal variability

open access: yes, 2023
<jats:p>Abstract. Earth system models suggest that anthropogenic climate change will influence marine phytoplankton over the coming century with light-limited regions becoming more productive and nutrient-limited regions less productive ...
Lovenduski, Nicole S.   +4 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

open access: yesFEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

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