Results 51 to 60 of about 1,550,292 (307)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Attribution of the July–August 2013 heat event in Central and Eastern China to anthropogenic greenhouse gas emissions

Environmental Research Letters, 2017
In the midsummer of 2013, Central and Eastern China (CEC) was hit by an extraordinary heat event, with the region experiencing the warmest July–August on record.
Shuangmei Ma, Tianjun Zhou, Dáithí A Stone, Oliver Angélil, Hideo Shiogama   +4 more
doaj   +1 more source

Internal variability in competence †

, 2002
Abstract To the non-linguist one of the most obvious facts about natural languages is the availability of ranges of, often subtly, differing ways of expressing the same linguistic meaning, where the differences correlate with values on non-linguistic parameters.
openaire   +2 more sources

Old World megadroughts and pluvials during the Common Era [PDF]

, 2015
Climate model projections suggest widespread drying in the Mediterranean Basin and wetting in Fennoscandia in the coming decades largely as a consequence of greenhouse gas forcing of climate.
an der Schrier, Gerard v, Andreu-Hayles, Laia, Baillie, Mike, Baittinger, Claudia, Bleicher, Niels, Bonde, Niels, Briffa, Keith R., Brown, David, Büntgen, Ulf, Carrer, Marco, Cook, Edward R., Cooper, Richard, Dittmar, Christoph, Esper, Jan, Frank, David, Griggs, Carol, Gunnarson, Björn, Gutierrez, Emilia, Günther, Björn, Haneca, Kristof, Helama, Samuli, Herzig, Franz, Heussner, Karl-Uwe, Hofmann, Jutta, Janda, Pavel, Kontic, Raymond, Krusic, Paul J., Kushnir, Yochanan, Kyncl, Tomáš, Köse, Nesibe, Levaniv c, Tom, Linderholm, Hans, Manning, Sturt, Melvin, Thomas M., Miles, Daniel, Neuwirth, Burkhard, Nicolussi, Kurt, Nola, Paola, Panayotov, Momchil, Popa, Ionel, Rothe, Andreas, School of Earth & Environmental Sciences, Scottish Oceans Institute, Seager, Richard, Seftigen, Kristina, Seim, Andrea, Svarva, Helene, Svoboda, Miroslav, Tegel, Willy, Thun, Terje, Timonen, Mauri, Touchan, Ramzi, Trotsiuk, Volodymyr, Trouet, Valerie, Walder, Felix, Wazny, Tomasz, Wilson, Rob, Zang, Christian, Čufar, Katarina   +58 more
core   +2 more sources

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Attribution of the record-high 2023 SST using a deep-learning framework

Environmental Research Communications
The global-mean sea surface temperature (SST) reached a record high in 2023, exceeding the 2016 record by 0.14 °C. This unprecedented change in global-mean SST has major implications for our understanding of internal variability and the forced response ...
Jamin K Rader, Charlotte J Connolly, M A Fernandez, Emily M Gordon   +3 more
doaj   +1 more source

Regionalization of anthropogenically forced changes in 3 hourly extreme precipitation over Europe

Environmental Research Letters, 2019
Future extreme precipitation events are expected to be influenced by climate change; however, the robustness of this anthropogenically forced response in respect to projection uncertainty especially for sub-daily extremes is not fully understood.
Parisa Hosseinzadehtalaei, Hossein Tabari, Patrick Willems   +2 more
doaj   +1 more source