Results 71 to 80 of about 1,550,292 (307)

Observed winds alone cannot explain recent Arctic warming and sea ice loss

Environmental Research: Climate
Since the 1980s, observations show the Arctic surface has warmed four times more than the global mean. Over the Arctic Ocean, this recent large warming is connected to sea ice loss.
Ash L Gilbert, Jennifer E Kay, Edward Blanchard-Wrigglesworth, David A Bailey, Marika M Holland, Alexandra Jahn, David P Schneider   +6 more
doaj   +1 more source

Internal Variability Increased Arctic Amplification During 1980–2022

Geophysical Research Letters, 2023
Since 1980, the Arctic surface has warmed four times faster than the global mean. Enhanced Arctic warming relative to the global average warming is referred to as Arctic Amplification (AA).
Aodhan J. Sweeney, Qiang Fu, Stephen Po‐Chedley, Hailong Wang, Muyin Wang   +4 more
doaj   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Southern Hemispheric Atmospheric Blocking Patterns in CESM‐LENS2: Effects of Reversal Versus Anomaly Approaches

Geophysical Research Letters
Atmospheric blocking is characterized as an anticyclonic flow structure which decelerates movement of weather systems in the mid‐latitudes. This study evaluates for the first time, Southern Hemispheric (SH) blocking representation in the Community Earth ...
Prasad B. Shelke, James A. Renwick
doaj   +1 more source

Inherent uncertainty disguises attribution of reduced atmospheric CO2 growth to CO2 emission reductions for up to a decade

Environmental Research Letters, 2020
The growth rate of atmospheric CO _2 on inter-annual time scales is largely controlled by the response of the land and ocean carbon sinks to climate variability.
Aaron Spring, Tatiana Ilyina, Jochem Marotzke   +2 more
doaj   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

The effect of spatial averaging and glacier melt on detecting a forced signal in regional sea level

Environmental Research Letters, 2017
We investigate the spatial scales that are necessary to detect an externally forced signal in regional sea level within a selected fixed time period. Detection on a regional scale is challenging due to the increasing magnitude of unforced variability in ...
Kristin Richter, Ben Marzeion, Riccardo Riva   +2 more
doaj   +1 more source

A Unifying Theory of Biological Function [PDF]

, 2017
A new theory that naturalizes biological function is explained and compared with earlier etiological and causal role theories. Etiological theories explain functions from how they are caused over their evolutionary history.
A Gordus, A Moreno, A Wouters, AA Faisal, B Brembs, B Nanay, C Boorse, C Boorse, DC Dennett, DJ Buller, DJ Kiviet, DM Walsh, DM Walsh, J Bigelow, J Garson, J. H. van Hateren, JH Hateren van, JH Hateren van, JH Hateren van, JH Hateren van, JH Hateren van, JM Gray, K Neander, K Neander, L Wright, M Mossio, M Perlman, M Perlman, P McLaughlin, PE Griffiths, PW Glimcher, R Cummins, R Cummins, RG Millikan, RG Millikan, RM Macnab, RS Galhardo, TT Hills   +37 more
core   +4 more sources

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

How Daily Temperature and Precipitation Distributions Evolve With Global Surface Temperature.

Earth's Future, 2019
The climate is an aggregate of the mean and variability of a range of meteorological variables, notably temperature (T) and precipitation (P). While the impacts of an increase in global mean surface temperature (GMST) are commonly quantified through ...
Bjørn Hallvard Samset, Camilla Weum Stjern, Marianne Tronstad Lund, Christian Wilhelm Mohr, Maria Sand, Anne Sophie Daloz   +5 more
doaj   +1 more source