Results 61 to 70 of about 1,550,292 (307)

Identifying teleconnections and multidecadal variability of East Asian surface temperature during the last millennium in CMIP5 simulations [PDF]

, 2019
We examine the relationships in models and reconstructions between the multidecadal variability of surface temperature in East Asia and two extratropical modes of variability: the Atlantic Multidecadal Oscillation (AMO) and the Pacific Decadal ...
Joshi, Manoj, Osborn, Timothy, Ratna, S. B., Wang, Jianglin, Yang, Bao   +4 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

The Impact of Internal Variability on Benchmarking Deep Learning Climate Emulators

Journal of Advances in Modeling Earth Systems
Full‐complexity Earth system models (ESMs) are computationally very expensive, limiting their use in exploring the climate outcomes of multiple emission pathways.
Björn Lütjens, Raffaele Ferrari, Duncan Watson‐Parris, Noelle E. Selin   +3 more
doaj   +1 more source

The Impact of Pictorial Display on Operator Learning and Performance [PDF]

, 1984
The effects of pictorially displayed information on human learning and performance of a simple control task were investigated. The controlled system was a harmonic oscillator and the system response was displayed to subjects as either an animated ...
Jagacinski, R. J., Messing, L. J., Miller, R. A.   +2 more
core   +1 more source

Causes of differences in model and satellite tropospheric warming rates [PDF]

, 2017
In the early twenty-first century, satellite-derived tropospheric warming trends were generally smaller than trends estimated from a large multi-model ensemble.
Bonfils, Céline, Cvijanovic, Ivana, England, Matthew H., Flato, Gregory M., Fu, Qiang, Fyfe, John C., Hawkins, Ed, Mann, Michael E., Mears, Carl, Meehl, Gerald A., Painter, Jeffrey F., Pallotta, Giuliana, Po-Chedley, Stephen, Santer, Benjamin D., Wentz, Frank J., Zou, Cheng-Zhi   +15 more
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Converged ensemble simulations of climate: possible trends in total solar irradiance cannot explain global warming alone

Frontiers in Earth Science
We address the hypothetical question of whether an increasing total solar irradiance (TSI) trend, without anthropogenic contributions, could be sufficient to explain the ongoing global warming.
Gábor Drótos, Gábor Drótos, Mátyás Herein, Mátyás Herein, Mátyás Herein, Tímea Haszpra, Imre M. Jánosi, Imre M. Jánosi   +7 more
doaj   +1 more source

Spurious Indo‐Pacific Connections to Internal Atlantic Multidecadal Variability Introduced by the Global Temperature Residual Method

Geophysical Research Letters, 2023
The relative contributions of external forcing and internal processes to the observed spatial and temporal characteristics of “Atlantic Multidecadal Variability” (AMV) are still under debate.
Clara Deser, Adam S. Phillips
doaj   +1 more source

On the Gamma Ray Burst Origin of Extremely Energetic Cosmic Rays

, 2009
Air shower experiments have detected cosmic ray events of energies upto 300 EeV. Most likely these cosmic rays have originated from compact objects. Their exact sources are yet to be identified.
Abraham, Amati, Bhattacharjee, Bird, Blasi, Cobb, Dolag, Fragile, Ghirlanda, Greisen, Gupta, Gupta, Hayashida, Liang, Liang, Miralda-Escudé, Murase, Mészáros, Mészáros, Nayantara Gupta, Pe’er, Pe’er, Pian, Pilla, Porciani, Razzaque, Rees, Sigl, Soderberg, Stanev, Vietri, Vietri, Wang, Waxman, Waxman, Waxman, Zatsepin, Zhang, Zhang, Zhang   +39 more
core   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source