Internal variability and forcing influence model-satellite differences in the rate of tropical tropospheric warming. [PDF]
Proc Natl Acad Sci U S A, 2022 Po-Chedley S +6 more
europepmc +1 more source
Internal Variability in Regional Climate Downscaling at the Seasonal Scale [PDF]
, 2007 To study the internal variability of the model and its consequences on seasonal statistics, large ensembles of twenty 3-month simulations of the Canadian Regional Climate Model (CRCM), differing only in their initial conditions, were generated over ...
de Elia, Ramon +2 more
core +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Greenhouse warming and internal variability increase extreme and central Pacific El Niño frequency since 1980. [PDF]
Nat Commun, 2023 Gan R, Liu Q, Huang G, Hu K, Li X.
europepmc +1 more source
Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy
Molecular Oncology, EarlyView.We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley +1 more source
CMIP6 near-term and long-term projections of Eurasian winter cooling trend and cold extremes
Environmental Research LettersIt is well-known that climate warming increases air temperature and reduces cold extremes in the long-term. But internal variability strongly modulates the variability of temperature at mid- and- high latitudes, for example, causing the remarkable ...
Xinping Xu +3 more
doaj +1 more source
What caused the recent “Warm Arctic, Cold Continents” trend pattern in winter temperatures?
Geophysical Research Letters, 2016 The emergence of rapid Arctic warming in recent decades has coincided with unusually cold winters over Northern Hemisphere continents. It has been speculated that this “Warm Arctic, Cold Continents” trend pattern is due to sea ice loss.
Lantao Sun +2 more
doaj +1 more source
Ensemble bias correction of climate simulations: preserving internal variability. [PDF]
Sci Rep, 2021 Vaittinada Ayar P, Vrac M, Mailhot A.
europepmc +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
Environmental Research: ClimateWe examine sources of uncertainty in projections of Arctic amplification (AA) using the CMIP6 multi-model (MM) ensemble and single model initial-condition large ensembles of historical and future scenario simulations.
Stephanie Hay +2 more
doaj +1 more source