Results 41 to 50 of about 122,564 (264)

STRUKTUR ANATOMIS VALVULA INTESTINALIS PARI GITAR (Rhinobatos typus)

Florea: Jurnal Biologi dan Pembelajarannya, 2019
Rhinobatos typus is included in Elasmobranchii Subclasses which has a unique intestine structure on internal part forms folds called valvula intestinalis as extension surface of food absorption.
Kusrini Kusrini, La Aba
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Polazne crte u Sredozemnome moru : s posebnim osvrtom na pitanje korekcije ravnih polaznih crta Republike Hrvatske

Poredbeno Pomorsko Pravo, 2011
U radu se analizira primjena pravila međunarodnoga prava mora o vanjskim granicama unutrašnjih morskih voda u praksi obalnih država Sredozemlja. Uz nacionalne propise kojima su defi nirane normalne ili ravne polazne crte ispred njihovih obala, s ...
Marina Vokić Žužul, Valerija Filipović   +1 more
doaj  

Study on sloshing simulation in the independent tank for an ice-breaking LNG carrier

International Journal of Naval Architecture and Ocean Engineering, 2020
As the LNG carrier operates in ice covered waters, it is key to ensure the overall safety, which is related to the coupling effect of ice-breaking process and internal liquid sloshing. This paper focuses on the sloshing simulation of the ice-breaking LNG
Shifeng Ding, Gang Wang, Qiuming Luo
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Assessment of biological activity of natural iron-containing mineral waters at their internal application

Journal of Education, Health and Sport, 2020
In experiments on rats of the Wi-star line, the influence of two iron-containing weakly mineralized mineral waters with a high content of organic matter (MW) from the sources № 13 and № 15 of Skhidnytsia deposit (Ukraine).
K. D. Babov, S. G. Gushcha, I. O. Voloshenyuk, B. A. Nasibullin, N. S. Badiuk, I. B. Zabolotna   +5 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Turbulent Properties of Internal Waves in the South China Sea [PDF]

Oceanography, 2011
Luzon Strait and South China Sea waters are among the most energetic internal wave environments in the global ocean. Strong tides and stratification in Luzon Strait give rise to internal waves that propagate west into the South China Sea.
Louis St. Laurent, Harper Simmons, Tswen Yung Tang, YuHuai Wang   +3 more
doaj  

Water Security and International Law

Potchefstroom Electronic Law Journal, 2017
The article explores water security from an international law point of view. The article argues that in order to better understand water security it is important to focus on the function of international water law. Even though water security is a relatively recent concept it was latent in the process of the evolution of international water law.    In
openaire   +8 more sources

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source