Results 61 to 70 of about 668,736 (310)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Turbulent Properties of Internal Waves in the South China Sea [PDF]

open access: yesOceanography, 2011
Luzon Strait and South China Sea waters are among the most energetic internal wave environments in the global ocean. Strong tides and stratification in Luzon Strait give rise to internal waves that propagate west into the South China Sea.
Louis St. Laurent   +3 more
doaj  

Oceanus. [PDF]

open access: yes, 1994
v. 37, no.
Woods Hole Oceanographic Institution.
core   +1 more source

Determination of dimethyl selenide and dimethyl sulphide compounds causing off-flavours in bottled mineral waters [PDF]

open access: yes, 2016
Sales of bottled drinking water have shown a large growth during the last two decades due to the general belief that this kind of water is healthier, its flavour is better and its consumption risk is lower than that of tap water.
Caixach Gamisans, Josep   +3 more
core   +2 more sources

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

open access: yesFEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon   +6 more
wiley   +1 more source

Reduced phosphorus loads from the Loire and Vilaine rivers were accompanied by increasing eutrophication in the Vilaine Bay (south Brittany, France) [PDF]

open access: yesBiogeosciences, 2019
The evolution of eutrophication parameters (i.e., nutrients and phytoplankton biomass) during recent decades was examined in coastal waters of the Vilaine Bay (VB, France) in relation to changes in the Loire and Vilaine rivers. Dynamic linear models were
W. Ratmaya   +8 more
doaj   +1 more source

Water Security and International Law

open access: yesPotchefstroom Electronic Law Journal, 2017
The article explores water security from an international law point of view. The article argues that in order to better understand water security it is important to focus on the function of international water law. Even though water security is a relatively recent concept it was latent in the process of the evolution of international water law.    In
openaire   +8 more sources

Anisakis infection in allis shad, Alosa alosa (Linnaeus, 1758), and twaite shad, Alosa fallax (Lacépède, 1803), from Western Iberian Peninsula Rivers : zoonotic and ecological implications [PDF]

open access: yes, 2015
Acknowledgments The authors would like to thank M. N. Cueto and J.M. Antonio (ECOBIOMAR) for their excellent technical support and also Rodrigo López for making the map of the study area.
Antunes, C.   +7 more
core   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

open access: yesFEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold   +11 more
wiley   +1 more source

Assessment of biological activity of natural iron-containing mineral waters at their internal application

open access: yesJournal of Education, Health and Sport, 2020
In experiments on rats of the Wi-star line, the influence of two iron-containing weakly mineralized mineral waters with a high content of organic matter (MW) from the sources № 13 and № 15 of Skhidnytsia deposit (Ukraine).
K. D. Babov   +5 more
doaj   +1 more source

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