Results 71 to 80 of about 2,888,152 (219)

Internalized weight stigma, metabolic syndrome, and inflammation in postmenopausal women with obesity

Brain, Behavior, & Immunity - Health
Objective: To determine the relationship of internalized weight stigma with metabolic syndrome (MetS) and markers of inflammation. Methods: Postmenopausal women with obesity (N = 101) with high or low scores on the Weight Bias Internalization Scale ...
Rebecca L. Pearl, Stephen D. Anton, Danielle Saunders, Marian Hernandez, Laurie C. Groshon, Miriam Sheynblyum, Dakota L. Leget, Christian McLaren, Sarah Vial, Lecsy Gonzalez, Kevin Wu, Gayane Barsamyan, Thomas A. Wadden   +12 more
doaj   +1 more source

A Decoy‐Receptor‐Armed Biomimetic Nanotherapeutic With Inherent Tropism for Conserved Pathogenic Macrophages for Treating Osteoarthritis and Intervertebral Disc Degeneration

Advanced Science, EarlyView.
A biomimetic doppelgänger nanosystem neutralizes extracellular inflammatory cytokines and silences intracellular pyroptosis, reprogramming pathogenic macrophages to attenuate both joint and spine degeneration. ABSTRACT Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) are debilitating musculoskeletal disorders driven by shared ...
Fudong Li, Bin Zhang, Zhiqiu Zhang, Bing Zheng, Linhui Han, Chen Yan, Jialin Li, Kaiqiang Sun, Tianyi Zhao, Jiangang Shi   +9 more
wiley   +1 more source

Photobiomodulation‑Engineered Extracellular Vesicles Enhance Neural Differentiation via UFL1‑Mediated UFMylation in Spinal Cord Injury

Advanced Science, EarlyView.
Photobiomodulated microglia release engineered extracellular vesicles that deliver UFL1 to the injured spinal cord. UFL1 competitively binds p53 with MDM2, inhibiting p53 ubiquitination and stabilizing p53 signaling. This dual mechanism simultaneously promotes anti‐inflammatory microglial polarization and directs neural stem cell differentiation toward
Yunxiao Fang, Zuomeng Wu, Ruocheng Guo, Cancan Wang, Yue Qin, Yixiang Dong, Aoyun Li, Ao Liu, Chongyu Jia, Tianyu Han, Peiwen Song, Lei Chen, Cailiang Shen   +12 more
wiley   +1 more source

Examining the effect of weight‐related recruitment information on participant characteristics: A randomized field experiment

Obesity Science & Practice
Objective Although 82% of American adults have a body mass index (BMI) of over 25, individuals with elevated BMI are considered difficult to recruit for studies.
Christy Wang, Jeffrey M. Hunger, Joseph Liao, David Figueroa, Alejandra Lopez, A. Janet Tomiyama   +5 more
doaj   +1 more source

Overweight and Lonely? A Representative Study on Loneliness in Obese People and Its Determinants

Obesity Facts, 2019
Obesity is associated with physical and medical restrictions and comorbidities, but it also entails psychosocial effects such as social isolation and feelings of rejection.
Franziska U. Jung, Claudia Luck-Sikorski   +1 more
doaj   +1 more source

Universal Battery Capacity Degradation Forecasting Driven by Foundation Models Across Diverse Chemistries and Conditions

Advanced Science, EarlyView.
A unified time‐series forecasting framework learns transferable battery capacity‐degradation patterns from 20 heterogeneous datasets spanning chemistries, formats, temperatures, and cycling conditions. A single model delivers competitive predictions on both known and previously unseen datasets, while physics‐guided representation learning improves ...
Joey Chan, Huan Wang, Zhen Chen, Haoyu Pan, Wei Wu, Zirong Wang, Ershun Pan, Min Xie, Lifeng Xi   +8 more
wiley   +1 more source

Supramolecular Degraders: An Emerging Paradigm in Targeted Protein Degradation

Advanced Science, EarlyView.
Dynamic supramolecular assembly reshapes targeted protein degradation by coordinating modular degrader construction, delivery, functional integration, and intracellular assembly or activation across proteasomal, endosomal–lysosomal, and autophagy–lysosomal pathways.
Kongjun Liu, Xue Yuan, Yan Zhou, Rui Yuan, Shaocheng Xie, Yong Chen, Peiyi Wang, Jianmei Gao, Qihai Gong   +8 more
wiley   +1 more source

Corrigendum: Examining the Conceptual and Measurement Overlap of Body Dissatisfaction and Internalized Weight Stigma in Predominantly Female Samples: A Meta-Analysis and Measurement Refinement Study

Frontiers in Global Women's Health, 2022
Jessica F. Saunders, Sarah Nutter, Shelly Russell-Mayhew   +2 more
doaj   +1 more source

Interactions of internalized weight bias with fear of weight gain and perfectionism and their associations with disordered eating

, 2023
In recent years, weight stigma has received increased attention in research as a possible risk factor and catalyst for eating disorder development (e.g., Keast et al., 2023; Lee et al., 2021).
Hannah Fitterman-Harris, Savannah Hooper, Cheri A Levinson   +2 more
core   +1 more source

Phase Separation, Material State, and Condensate Fate in Mammalian Autophagy

Advanced Science, EarlyView.
ABSTRACT Biomolecular phase separation has emerged as a key organizing principle in macroautophagy (hereafter autophagy). In mammalian cells, phase‐separated condensates not only serve as substrates for selective degradation, but also act as dynamic platforms for cargo recognition, signaling integration, and autophagosome assembly.
Yuanqiang Lin, Mingran Dai, Enyong Dai, Rui Kang, Daniel J. Klionsky, Daolin Tang, Yu Sun, Ningning Lv, Junnan Jiang   +8 more
wiley   +1 more source