Results 61 to 70 of about 2,888,152 (219)

Genetic Ablation and Multi‐Omics Profiling Reveal CEP55 as a Key Driver of Tumorigenesis in Diverse Cancer Models

Advanced Science, EarlyView.
Genetic ablation of Cep55 in Pten‐deficient mouse models delays tumorigenesis. Integrated multi‐omics analyses (proteomics, phosphoproteomics, and spatial transcriptomics) reveal that CEP55 regulates oncogenic signaling (RAS/ERK, PI3K/AKT), integrin/FAK‐mediated adhesion, extracellular matrix (ECM) remodeling, and endocytosis.
Behnam Rashidieh, Yuanhao Yang, Amanda Louise Bain, Phillip Theron, Catharina Vosloo, Sahar Keshvari, Parinaz Ahangar, Brydie Bowden, Simon M. Tria, Ben B. Wang, Sandra Isenmann, Nicholas J. Westra van Holthe, Zherui Xiong, Hani Vu, Sowmya Sharma, Asmerom Sengal, J. Alejandro Lopez, John Finnie, Antonella Papa, Pascal H.G. Duijf, Quan Nguyen, Pirjo M. Apaja, Kum Kum Khanna   +22 more
wiley   +1 more source

CLRe: A Synergistic Dual‐Engine Framework for One‐Step Retrosynthesis Prediction

Advanced Science, EarlyView.
CLRe uses a contrastive difficulty score to order pretrained seq2seq fine‐tuning for retrosynthesis. Reaction embeddings define the ranking score, and a cumulative easy‐to‐hard schedule expands from the easiest subset to the full training set while earlier examples remain active.
Tianhao Su, Xitao Wang, Musen Li, Guanhua Qin, Shunbo Hu, Tong‐Yi Zhang   +5 more
wiley   +1 more source

Psychological interventions for internalized weight stigma: a systematic scoping review of feasibility, acceptability, and preliminary efficacy

Journal of Eating Disorders
Background Internalized weight stigma (IWS) is highly prevalent and associated with deleterious mental and physical health outcomes. Initiatives are needed to address IWS and promote effective coping and resilience among individuals who are exposed to ...
Laura D’Adamo, Abigail T. Shonrock, Lawrence Monocello, Jake Goldberg, Lauren H. Yaeger, Rebecca L. Pearl, Denise E. Wilfley   +6 more
doaj   +1 more source

Stigmatizing weight experiences in health care: Associations with BMI and eating behaviours

Obesity Science & Practice, 2019
Summary Introduction Individuals with overweight or obesity often experience stigmatizing weight‐related interactions in health care, though how these experiences are associated with body mass index (BMI) and eating behaviour is unknown.
Jocelyn E. Remmert, Alexandra D. Convertino, Savannah R. Roberts, Kathryn M. Godfrey, Meghan L. Butryn   +4 more
doaj   +1 more source

Engineered Brain‐Targeted Exosomes Delivering FGF1 for Sustained Glycemic Regulation and Multitarget Neurovascular Protection in Diabetic Stroke

Advanced Science, EarlyView.
ABSTRACT Diabetic stroke is characterized by a hyperglycemic and pro‐inflammatory microenvironment that exacerbates neurovascular dysfunction. However, the blood–brain barrier (BBB) remains a formidable obstacle, restricting the delivery of most therapeutic molecules.
Bixin Shen, Chengxiang Zhang, Junhui Wang, Xichong Zhong, Shihao Chen, Xue Wang, Xiaokun Li, Li Lin   +7 more
wiley   +1 more source

Bariatric surgery patients’ perceptions of weight-related stigma in healthcare settings impair post-surgery dietary adherence

Frontiers in Psychology, 2016
Background: Weight-related stigma is reported frequently by higher body-weight patients in healthcare settings. Bariatric surgery triggers profound weight loss.
Danielle M. Raves, Alexandra Brewis, Sarah Trainer, Seung Yong Han, Amber Wutich   +4 more
doaj   +1 more source

Weight-related teasing and internalized weight stigma predict abnormal eating attitudes and behaviours in Emirati female university students [PDF]

, 2016
© 2016 Elsevier Ltd. This cross-sectional study examined the relationship between abnormal eating attitudes, weight teasing, internalized weight stigma and self-esteem in the United Arab Emirates in a sample of 420 female Emirati undergraduate students ...
O'Hara, Lily, O\u27Hara, Lily, Tahboub-Schulte, Sabrina, Thomas, Justin   +3 more
core   +1 more source

RNA Promotes Synapsin Condensates That Organize Synaptic Vesicles in Live Neurons and Enable Localized Translation in Reconstituted System

Advanced Science, EarlyView.
Condensates at synapses organize synaptic vesicles (SVs) and are crucial for efficient neurotransmitter release, yet how RNA contributes to this mesoscale architecture remains poorly understood. Here we uncover that RNA modulates synapsin–driven condensates.
Branislava Rankovic, Zachary M. Geisterfer, Akshita Chhabra, Vladimir M. Jovanovic, Ian Seim, Christian Hoffmann, Antonela Condric, Gerard Aguilar Pérez, Rinse de Boer, Lars T. Hofstede, Jingao Sun, Kiara Freitag, Katja Nowick, Marina Jendrach, Frank L. Heppner, Vladimir Despic, Michaela Müller‐McNicoll, Stephan Sigrist, Geert van den Bogaart, Sofiia Reshetniak, Amy S. Gladfelter, Dragomir Milovanovic   +21 more
wiley   +1 more source

Translation and Initial Psychometric Evaluation of a Korean Version of the Modified Weight-Bias Internalization Scale (K-WBIS) in Korean Adult Women

Obesities
Research has examined the negative consequences of internalized weight bias on mental health (e.g., disordered eating, depression, anxiety). In South Korea’s patriarchal society, appearance rather than ability or talent is considered the principal ...
Si Woo Chae, Katrina T. Obleada, Janet D. Latner   +2 more
doaj   +1 more source

Learning Work Function via Implicit Reasoning on Electrostatic Potential Landscapes

Advanced Science, EarlyView.
StructPot‐CLR establishes a cross‐modal contrastive learning framework that aligns the crystal structures of 2D materials with plane‐averaged electrostatic potential landscapes for physically informed work‐function prediction. The model achieves an MAE of 0.265 eV and an R2 of 0.902 on the held‐out test set while accurately preserving key morphological
Haoyu Wan, Yue Wu, Tianhao Su, Deng Pan
wiley   +1 more source