Results 121 to 130 of about 241,868 (262)

A Wireless 3D Magneto‐Mechanical Stimulation Platform Drives In Situ Chondrogenic Commitment of Endogenous MSCs

Advanced Science, EarlyView.
An intracellular magneto‐mechanical platform utilizing MSC‐targeted nanomotors is developed. After intra‐articular delivery, these nanomotors target endogenous BMSCs and are actuated within lysosomes to execute trans‐planar rotational‐bouncing motions under a rotating‐fluctuating 3D magnetic field, generating amplified mechanical stimulation.
Zhenguang Li, Li Peng, Laiya Lu, Yingying Wang, Xiaolei Chen, Feng Yin, Cuijun Deng, Yu Cheng   +7 more
wiley   +1 more source

CCL3 and IL‐7 Synergistically Enhance CAR‐T Efficacy in Solid Tumors

Advanced Science, EarlyView.
Synergistic delivery of CCL3 and IL‐7 by CAR‐T cells overcomes the immunosuppressive tumor microenvironment by enhancing cell infiltration, survival, and local immune reprogramming. This also establishes positive feedback that amplifies anti‐tumor activity and memory responses in both CAR‐T and endogenous T cells, presenting a robust therapeutic ...
Huanpeng Chen, Xiaoyun Luo, Huixin Gao, Yujing Ke, Yu Zhan, Xiaoting Xu, Xiaoxiao Xiong, Fengjiao Wei, Si Yang, Zhonghua Liu, Bolan Yu, Zhaofeng Huang, Yingjie Bian   +12 more
wiley   +1 more source

International cooperation and the challenge of internet accessibility in Caribbean territories: example of a collaborative platform between the University Hospital of Martinique and Ramón González Coro Hospital in Cuba, through the French PRPH-3 program. [PDF]

BMC Med Educ, 2023
Houpert R, Almont T, Mésenge C, Kleinebreil L, Forlini L, Magnone B, Leroux V, Vestris M, Montabord C, Carmenate J, Galán Y, Rubio MC, Enriquez R, Burte C, Gatimel N, Bujan L, Kara N, Edwige O, Huyghe É, Joachim C, Véronique-Baudin J.   +20 more
europepmc   +1 more source

All‐Flex Plasma Patch for In Vivo Delivery of Reactive Species

Advanced Science, EarlyView.
A fully flexible plasma patch enables stable, conformal treatment on complex biological surfaces and enhances transdermal delivery of reactive species. This platform achieves significant tumor suppression in vivo and reveals coordinated regulation of calcium signaling, metabolism, and programmed cell death, providing a promising strategy for safe and ...
Luxiang Zhao, Abulaihaiti Tuergong, Hanshu Yang, Shuang Xue, An Yan, Mingzhen Wang, Weilong Song, Wenzhe Si, Ruixue Wang   +8 more
wiley   +1 more source

Training young Russian physicians in Uganda–A unique program for introducing global health education in Russia

Annals of Global Health, 2014
B.A. Ziganshin, L.M. Yausheva, M. Sadigh, A. Pichugin, A. Ziganshin, A. Sozinov, M. Sadigh   +6 more
doaj   +1 more source

Orthopaedic Disorders in Cerebral Palsy in International Cooperation Projects: A Descriptive Cross-Sectional Study. [PDF]

Int J Environ Res Public Health, 2021
Garrido-Ardila EM, Caro-Puertolas B, Jiménez-Palomares M, Montanero-Fernández J, Rodríguez-Domínguez T, Rodríguez-Mansilla J.   +5 more
europepmc   +1 more source

Mechanical Activation of Piezo1 Drives Osteoarthritis Through Kdm5c‐Mediated Epigenetic Silencing

Advanced Science, EarlyView.
Excessive mechanical stress activates Piezo1, triggering Ca2+‐dependent cytoskeletal forces that deform the nucleus and reduce H3K4me3. Kdm5c demethylates H3K4me3 at Col2a1 and Runx3 promoters. Kdm5c knockout rescues degradation. Repurposed telmisartan directly inhibits Kdm5c, blocking this axis and showing disease‐modifying efficacy in mouse OA models
Tianyou Kan, Xuran Li, Han Wang, Lin Sun, Yao Wang, Jiangdong Wu, Junqi Cui, Yiqi Yang, Kai Yuan, Linyang Chu, Liao Wang, Hanjun Li, Mengning Yan, Zhifeng Yu   +13 more
wiley   +1 more source

First corpus callosotomy for medically refractory epilepsy in The Gambia: an international cooperation case report and historical review. [PDF]

Acta Epileptol
Gal ZT, Manneh EK, Gupta S, Luiselli GA, Cham M, Ceesay A, Nyassi M, Jobe Y, Oguocha R, Barry M, Gomez MF, Jammeh M, Bojang O, Jagne T, Jallow F, Njie A, Jallow CS, Bittaye M, Joof M, Marenah KS, Sanchez YC, Mbaye M, Doumbia N, Kangakan S, Sarpong P, Alkhateeb MA, Cobas ER, Janneh L, Rolston JD, Jabang JN.   +29 more
europepmc   +1 more source

COVID-19 in Central Asia: Uzbekistan's new approach to international cooperation. [PDF]

Lancet Reg Health Eur, 2021
Shadmanov A, Boklage E, Storozhenko O, Jansen A, COVID-19 mission team for Uzbekistan.   +4 more
europepmc   +1 more source

A Chemically Defined Four‐Component Self‐Adjuvanting Tn Vaccine Activating Mincle, FcγR, and CD206 for Enhanced Antitumor Immunity

Advanced Science, EarlyView.
A fully synthetic four‐component vaccine has been developed combining Tn antigen, vizantin (Mincle agonist), rhamnose (antibody recruitment), and mannose (CD206 targeting). By synergistically activating Mincle, FcγR, and CD206 pathways, it elicits strong IgG switching and cytotoxic T‐cells, significantly inhibiting tumors in mice.
Wenbo Ming, Renyu Zhang, Xiaohui Li, Guiqi Li, Yu Niu, Deying Yang, Xiang Luo, Jun Liao, Zhongqiu Liu, Guochao Liao   +9 more
wiley   +1 more source