Results 61 to 70 of about 9,501,817 (347)
Landscape of BRAF transcript variants in human cancer
Molecular Oncology, EarlyView.We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda +5 more
wiley +1 more source
Response to the Repeal of China’s One-Child Policy: Part 3 – Managing a Population [PDF]
, 2015 In the last of our three-part series on China, the department considers the demographic implications behind the decision to repeal the one-child policy. Will families want to enlarge their families?
International Development,
core
TRPM8 levels determine tumor vulnerability to channel agonists
Molecular Oncology, EarlyView.TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo +18 more
wiley +1 more source
Response to the Repeal of China’s One-Child Policy: Part 2 – The Economic Transformation [PDF]
, 2015 In the second of our three-part series, academics from the Department of International Development consider the consequences for China’s economic growth and productivity following the formal repeal of the one-child ...
International Development,
core
Molecular Oncology, EarlyView.In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton +17 more
wiley +1 more source
Research Excellence Framework results now in – LSE tops tables! [PDF]
, 2014 Research Excellence Framework results confirm that since 2009 the LSE’s International Development department has become established as one of the leading departments of International Development study in the ...
International Development,
core
Private Donations for International Development [PDF]
, 2004 Abstract The chapter starts by considering the extent to which development benefits from philanthropic effort, showing that a great deal of philanthropy in rich industrialised countries is aimed at domestic concerns, and may vary with household income; the super‐rich are treated here as a special case.
Micklewright, John, Wright, Anna
openaire +4 more sources
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
PCD Online Journal, 2017 This article develops a theory of European power as ‘governmentality’, with a particular reference to European Union (EU)’s engagement of civil society in Indonesia through a package of “civil society strengthening programs”.
Ahmad Rizky Mardhatillah Umar
doaj +1 more source
Welcome to the LSE. It’s not for the faint-hearted. [PDF]
, 2015 The Department of International Development extends a very warm welcome to our incoming students.
International Development,
core