Results 41 to 50 of about 23,132,644 (262)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Constructing education as human capital in a transitional society: A case study of Somaliland's education reconstruction [PDF]

, 2011
Copyright 2011 @ Symposium Journals Ltd.The purpose of this article is to critically examine Somaliland's post-conflict education reconstruction. The work includes documentary analysis of the Somaliland Education Policy.
Bradford, Simon, Hassan Ahmed, Simon Bradford, Ahmed, Hassan, Bradford, S, Ahmed, H   +5 more
core   +1 more source

Unlocking New Horizons: Teacher Mobility and Competence Growth via Erasmus Exchange Programs

Education Sciences
This qualitative study investigates how short-term international mobility—specifically Erasmus staff exchange—nurtures educational leadership in an increasingly globalized landscape.
Ioana-Simona Ivasciuc, Nicolae Marinescu, Ana Ispas   +2 more
doaj   +1 more source

Erasmus Öğrenci Öğrenim Hareketliliği Programının 2007 Yılında Programdan Yararlanan Türk Öğrenciler Üzerindeki Etkileri

Ankara Avrupa Çalışmaları Dergisi, 2010
Türk yükseköğretim sistemi, giderek artan biçimde uluslararası olma özelliği göstermektedir. Uluslararası olmanın boyutlarından biri, değişim programları aracılığıyla öğrencilerin yurt dışı yükseköğretim kurumlarında eğitim görmeleri ve yeni kültürlerle ...
Ranâ Kasapoğlu Önder, Ali Balcı
doaj   +1 more source

Investigating the Predictors of the International Baccalaureate Diploma Programme Outcome Scores

Sakarya University Journal of Education, 2020
The main purpose of this investigation was to explore the predictors of the International Baccalaureate Diploma Programme (IBDP) outcome scores. A purposive sample of 123 high school students was drawn from a selective private school in a city in Eastern
Öykü Dulun
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Students and staff language competence improving as a main condition of education internationalizaion

Вестник Самарского государственного технического университета. Серия: Психолого-педагогические науки, 2016
This article deals with the problem of internationalization of education in a technical university. It draws line between the concepts of "internationalization" and "globalization" and defines the terms "inner" and "outer" internationalization.
Ludmila V. Paloiko, Daria A. Saraeva
doaj  

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source