Results 61 to 70 of about 2,490,434 (301)
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
EU at the UN: The Effects of its New Rights Agenda on International Social Structures [PDF]
, 2007 This study seeks to determine the effect of the EU’s human rights agenda on the international institution of human rights, and the resulting effect on interstate society.
Sylva, Douglas., Yoshihara, Susan,
core
FEBS Open Bio, EarlyView.ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand +2 more
wiley +1 more source
FEBS Open Bio, EarlyView.Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Maximizing the Impact of CSR in China [PDF]
, 2006 The past five years have seen a growing number of Corporate Social Responsibility (CSR) conferences in China, increasing participation by Chinese businesses in international multi-stakeholder processes, and the development of China-specific CSR standards.
core
Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs
FEBS Open Bio, EarlyView.Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner +7 more
wiley +1 more source
INSTRUMENTAL CAPACITY OF INTERNATIONAL BUSINESS IN MODERN CONDITIONS
Baltic Journal of Economic StudiesThe present study examines the institutional and instrumental capacity of international business in modern conditions. The purpose of the research is to identify and highlight the key institutional capabilities of the modern economy and the tools that ...
Georgii Logvynskyi
doaj +1 more source
DfID’s Last Stand: A Belated but Welcome Theory of Change on Mental Health and Development
Journal of Humanitarian Affairs, 2021 This article critiques the new Theory of Change (ToC) on mental health published by the UK’s Department for International Development (DfID) in the last fortnight of its existence.
Laura Davidson
doaj +1 more source
Caultron of Unwisdom: The Legislative Offensive on Insidious Foreign Influence in the Third Term of President Vladimir V. Putin, and ICCPR Recourse for Affect Civil Advocates [PDF]
, 2015 Part I discusses Russian and international statutory law. It briefly outlines the structure of the government of the Russian Federation and discusses relevant articles of its Constitution.
Callahan, Thomas M.
core +1 more source