Results 51 to 60 of about 400,120 (256)

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Do the pathways of child development before age three matter for development at primary school? Evidence from rural China

Humanities & Social Sciences Communications
The literature has shown that cognitive and non-cognitive development before the age of three is associated with children’s levels of development at later ages.
Lei Wang, Siqi Zhang, Scott Rozelle
doaj   +1 more source

Brazil’s 2019 BRICS Presidency: What to Expect from the Start of a New Decade of Cooperation and the J. Bolsonaro’s Administration

Vestnik RUDN. International Relations, 2018
BRICS is now entering a new decade of its activity. The institute enters a new decade in the conditions of a general multilateralism crisis, the growth of protectionist and nationalist sentiments even in the most liberal states, the leaders do not want ...
Irina Maximovna Popova
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Going Beyond the "Normative vs. Social" Standard: A Preliminary Framework for Evaluating the Legitimacy of International Institutions. [PDF]

Society, 2023
Liu P, Cao YH.
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Forest users' perceptions and institutional dynamics during covariate health-related shocks: Lessons from the Busitema Forest Reserve in Uganda

Scientific African
Increased dependency on the forest has resulted in rapid transformation of forest landscapes; this has been identified in the extensive literature as a significant mechanism for the spread of several zoonotic diseases, including the Ebola and COVID-19 ...
George Acquaah, Jude Ndzifon Kimengsi, Ametus Kuuwill, Alice Nakiyemba Were   +3 more
doaj   +1 more source

INTERNATIONAL REGIMES AND TRANSPORTATIONS; TIR REGIME AND ITS MAIN TRAITS [PDF]

Oradea Journal of Business and Economics
The paper aims to indicate that the processes of regionalization and globalization were in a great manner determined and influenced by collaboration and coordination among states.
Ciprian Beniamin BENEA, Adrian NEGREA
doaj   +1 more source