Results 91 to 100 of about 617,887 (285)

Antiemesis Corticosteroids Potentiate Checkpoint Blockade Efficacy by Normalizing the Immune Microenvironment in Metastatic Murine Breast Cancer

open access: yesAdvanced Science, EarlyView.
Corticosteroids improve the efficacy of immune checkpoint blockade therapy in metastatic murine breast cancer. By normalizing the tumor immune microenvironment, corticosteroids reduce immunosuppressive signals, restore T‐cell function, and promote antitumor immune responses, resulting in enhanced tumor control.
John D. Martin   +19 more
wiley   +1 more source

BUSM News and Notes [PDF]

open access: yes, 1982
Monthly newsletter providing updates of interest to the Boston University School of Medicine ...
Boston University School of Medicine Office of Informational Services
core  

CD20+FCRL4+ B Cells Activate CD8+ T Cells via MHC‐I Restriction in Nasopharyngeal Carcinoma Anti‐Tumor Immunity

open access: yesAdvanced Science, EarlyView.
CD20⁺FCRL4⁺ B cells in nasopharyngeal carcinoma actively cross‐present exogenous tumor antigens via MHC‐I, enhancing CD8⁺ T‐cell activation, memory formation, and cytotoxicity. IFNγ‐driven WDFY4 upregulation facilitates this process. These findings reveal an unconventional B‐cell–mediated antitumor mechanism and indicate potential relevance to ...
Benjian Zhang   +17 more
wiley   +1 more source

IgG‐Bridging–Seeded Synergistic Aggregation of SARS‐CoV‐2 Spikes Underlies Potent Neutralization by a Low‐Affinity Antibody

open access: yesAdvanced Science, EarlyView.
Low‐affinity antibodies are frequently disregarded in discovery pipelines. This work reports P5‐1C8, a Class 1 SARS‐CoV‐2 antibody with weak trimer binding (KD‐to‐IC50 > 3700‐fold) yet potent neutralization of Omicron JN.1. Structural, biophysical, functional, and coarse‐grained simulations collectively demonstrate that transient inter‐spike IgG ...
Niannian Lv   +29 more
wiley   +1 more source

Lithium Squarate as Sacrificing Electrolyte Additive for Prelithiation: Case Study in Zero‐Excess Lithium Metal Batteries

open access: yesAdvanced Science, EarlyView.
Active lithium loss (ALL) and capacity fade can be compensated by prelithiation, apparently simple via sacrificing additives e.g., lithium squarates. However, as a cathode additive it ruptures the cathode via gas evolution, while as an electrolyte additive it gets reductively depleted on anode side in course of solid electrolyte interphase (SEI ...
Ibrahim Lawan Abdullahi   +8 more
wiley   +1 more source

International Medical Graduates: The Australian Perspective

open access: yesAcademic Medicine, 2006
Australia, like many other developed countries, has faced medical workforce shortages. This situation has been attributed to the increasing demands from an aging population and a decline in the hours worked by medical practitioners. These shortages, which are usually in the areas of greatest medical need in Australia, have led to an increasing ...
openaire   +3 more sources

Assessing student perceptions of the Pharm.D. degree at a private tertiary medical university in India [PDF]

open access: yes, 2017
Background: Pharmacy education in India has expanded to include the Doctorate of Pharmacy degree (Pharm.D.). With clinical practice in early development, job opportunities in India are limited. Graduates often consider pharmacy opportunities abroad. Aims:
Birnie, Christine R.   +2 more
core   +1 more source

Free‐Volume Regulation Enables Significantly Enhanced Electrical Breakdown via Short‐Chain Molecular Spatial‐Positioning Intercalation into Poly(vinylidene fluoride)

open access: yesAdvanced Science, EarlyView.
An innovative molecular spatial‐positioning shimming strategy is developed to optimize the electrical properties of poly(vinylidene fluoride) (PVDF). By intercalating polyethylene wax (PE wax) short‐chain molecules into PVDF's free volume, the film achieves a significantly enhanced energy density of 32.67 J cm−3.
Ziyue Wang, Jiyang Xie, Wanbiao Hu
wiley   +1 more source

Creating a center for global health at the University of Wisconsin-Madison. [PDF]

open access: yes, 2008
Globalization, migration, and widespread health disparities call for interdisciplinary approaches to improve health care at home and abroad. Health professions students are pursuing study abroad in increasing numbers, and universities are responding with
Baumann, Linda   +7 more
core   +1 more source

Dissolution Study of Biodegradable Magnesium Silicide Thin Films for Transient Electronic Applications

open access: yesAdvanced Science, EarlyView.
Magnesium silicide (Mg2Si) is introduced as a narrow‐bandgap, biodegradable semiconductor for transient electronics. RF‐sputtered and annealed Mg2Si thin films show high intrinsic electrical conductivity and low thermal conductivity. The polycrystalline material undergoes hydrolysis in aquatic and composting environments with minimal cytotoxicity ...
Ji‐Woo Gu   +17 more
wiley   +1 more source

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