Results 51 to 60 of about 1,193,453 (300)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Управленческое консультирование, 2018 This article addresses the issue of justification of uses of force in historical perspective. Formation of the modern doctrine of Just War originated in ancient Greece and Rome.
Stanislav Valentinovich Korostelev
doaj
Naturally occurring radioactive material in pipeline scraping operations
Radiation Protection and EnvironmentRadioactive materials found naturally in the earth may become concentrated during petroleum development processes. This naturally occurring radioactive material (NORM) can be present in various forms, such as hydrocarbon sludge, scale, or metallic ...
Omar Y. Al-Somali, Emil M. Aliyev
doaj +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Localizing European and developmental central banking ideas [PDF]
, 2013 1\. Introduction 5 2\. The Life Cycle of an Alternative Policy Norm 7 3\. Competing Central Banking Norms 10 4\. Methodology 12 5\. The European Regional Norm Internationalized 12 6\.
Krampf, Arie
core +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Withdrawing from International Custom: Terrible Food, Small Portions [PDF]
, 2011 Curtis A. Bradley and Mitu Gulati’s Withdrawing from International Custom brings to mind the old joke recounted by Woody Allen in Annie Hall: “Two elderly women are at a Catskill mountain resort, and one of ’em says, ‘Boy, the food at this place is ...
Vázquez, Carlos Manuel
core +1 more source
FEBS Open Bio, EarlyView.ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand +2 more
wiley +1 more source
Taking Sides In Peacekeeping: Impartiality And The Future Of The United Nations [PDF]
, 2016 United Nations peacekeeping has undergone radical transformation in the new millennium. \u27Taking Sides in Peacekeeping\u27 explores this transformation and its implications, in what is the first conceptual and empirical study of impartiality in UN ...
Rhoads, Emily Paddon
core +2 more sources
FEBS Open Bio, EarlyView.Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman +4 more
wiley +1 more source