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Identification of a Nonribosomal Peptide Analog With Activity Against Multiple Gram‐Positive Bacteria via a Synthetic Bioinformatic Natural Product Discovery Approach

open access: yesAdvanced Science, EarlyView.
The genome of Rhodococcus erythropolis D‐1 was analyzed by bioinformatic tools to mine a novel nonribosomal peptide synthetase (NRPS) gene cluster. A nonribosomal peptide analog ZURJC5 associated with the NRPS was chemically synthesized. Through structure‐activity relationship studies, ZURJC28 was ultimately obtained and showed antibacterial activity ...
Keyi Chen   +9 more
wiley   +1 more source
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Effects of prednisone on the International Normalized Ratio

American Journal of Health-System Pharmacy, 2006
The effects of prednisone on the International Normalized Ratio (INR) values of a patient were examined.A 66-year-old white man with a history of multiple myeloma was treated in an ambulatory care anticoagulation clinic for deep vein thrombosis. His INR values were normal during therapy with warfarin 14 mg weekly and thalidomide 300 mg daily.
Julie A, Stading   +3 more
openaire   +2 more sources

Effect of Lepirudin on the International Normalized Ratio

Annals of Pharmacotherapy, 2005
BACKGROUND: Many patients receiving direct thrombin inhibitor (DTI) therapy require transition to warfarin. This transition may be complicated by DTI-induced elevations in the international normalized ratio (INR).
Jennifer L, Stephens   +3 more
openaire   +2 more sources

Fiddleheads and the International Normalized Ratio

New England Journal of Medicine, 1998
To the Editor: Many drugs and foods affect the response to oral anticoagulants.1 We describe a change in the international normalized ratio (INR) that was caused by the consumption of fiddleheads.
W.R. Bartle, Guylaine Ferland
openaire   +1 more source

Prothrombin Time/International Normalized Ratio

2013
Prothrombin time (PT) and/or International Normalized Ratio (INR) is the most commonly used coagulation assay in health care, to diagnose the risk of bleeding and to monitor oral anticoagulation therapy. This test is based on the principle that in citrated plasma, the addition of a thromboplastin and CaCl2 allows for formation of a stable clot.
openaire   +2 more sources

Management of Anticoagulation Therapy With the International Normalized Ratio

Journal of the American Academy of Nurse Practitioners, 1996
Nurse practitioners have both the education and the counseling skills to evaluate and manage patients receiving warfarin therapy. The benefits of such treatment should be weighed against potential risk before initiation of therapy. Patients receiving warfarin need to be closely monitored because of the narrow therapeutic range of the drug.
openaire   +2 more sources

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