Mechanical Activation of Piezo1 Drives Osteoarthritis Through Kdm5c‐Mediated Epigenetic Silencing
Excessive mechanical stress activates Piezo1, triggering Ca2+‐dependent cytoskeletal forces that deform the nucleus and reduce H3K4me3. Kdm5c demethylates H3K4me3 at Col2a1 and Runx3 promoters. Kdm5c knockout rescues degradation. Repurposed telmisartan directly inhibits Kdm5c, blocking this axis and showing disease‐modifying efficacy in mouse OA models
Tianyou Kan +13 more
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Genitourinary Pathology Society and International Society of Urological Pathology White Paper on Defining Indolent Prostate Cancer. [PDF]
Shah RB +28 more
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Global oncology pharmacy service levels and knowledge requirements: A review by the International Society of Oncology Pharmacy Practitioners. [PDF]
Ryan M +3 more
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Antimicrobial use guidelines for canine pyoderma by the International Society for Companion Animal Infectious Diseases (ISCAID). [PDF]
Loeffler A +9 more
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Why patient safety is akin to weaving textiles: an International Society for Quality in Health Care perspective on the 7th Global Ministerial Summit on Patient Safety 2025. [PDF]
Braithwaite J +5 more
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Synopsis of the antimicrobial use guidelines for canine pyoderma by the International Society for Companion Animal Infectious Diseases (ISCAID). [PDF]
Loeffler A +9 more
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Outcomes from the International Society of Nephrology Hemolytic Uremic Syndromes International Forum. [PDF]
Kavanagh D +20 more
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The Globalization of International Society
2017This chapter lays the conceptual and theoretical foundations for the volume. It begins by examining four accounts of the globalization of international society. Of these, only Bull and Watson offer a robust account of how the social order of states became global.
Reus-Smit, Christian, Dunne, Tim
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