Results 51 to 60 of about 3,862,277 (287)

International Standards for Digital Twins

Acta Infologica
Interest in digital twins has grown significantly due to the maturation of enabling technologies, including cloud computing, 5G, data storage, computing capabilities, the Internet of Things (IoT), Artificial Intelligence (AI), and machine learning.
Esra Kumaş
doaj   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

External examining: fit for purpose? [PDF]

, 2015
In a context of international concern about academic standards, the practice of external examining is widely admired for its role in defending standards.
Bloxham, Susan, Price, Margaret
core   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

International elections’ standards: achievements and problems

Московский журнал международного права, 2007
This article is devoted to international cooperation of Russia with the partner structures of foreign states on a bilateral basis and developing relations on a multilateral basis within international organizations concerned with the assurance of civil ...
S. N. Dorofeev
doaj   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

An Analytical Method to the Economics of Pumped Storage Power Plants Based on the Real Options Method

Energies
This paper develops an economic evaluation framework for pumped storage hydropower (PSH) projects based on real options, addressing the limitations of traditional economic evaluation methods that neglect investment flexibility and path dependence.
Weihao Wang, Jianbin Fan, Jian Le, Gong Zhang, Longxiang Chen, Lei Deng   +5 more
doaj   +1 more source

Challenges in the Analysis of Historic Concrete:Understanding the Limitations of Techniques, the Variability of the Material and the Importance of Representative Samples [PDF]

, 2020
The number of historically-significant concrete structures which require conservation and repair is ever-increasing. The use of unsuitable proprietary materials has led to poor quality repairs of historically-significant structures in the United Kingdom,
Abrams D. A., ASTM International, ASTM International, Axon E. O., Basheer P. A. M., BSI (British Standards Institution), BSI (British Standards Institution), BSI (British Standards Institution), BSI (British Standards Institution), BSI (British Standards Institution), BSI (British Standards Institution), BSI (British Standards Institution), BSI (British Standards Institution), BSI (British Standards Institution), Corish A. T., Department for Culture, Media and Sport, Eden M. A., English Heritage, Ishida T., Neville A. M., Neville A. M., Nordtest Method, Pasley C. W., Polivka M., Skinner M. G., St John D. A., Yeomans D.   +26 more
core   +2 more sources

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source