Results 81 to 90 of about 20,311,651 (285)

Interactive peer-guided examination preparation course for second-year international full-time medical students: quantitative and qualitative evaluation

GMS Journal for Medical Education, 2018
Background: It has been documented that international students face diverse challenges due to language and cultural barriers. International medical students suffer from personal distress, a lack of support and perform poorer than local fellow-students in
Huhn, Daniel, Al Halabi, Karam, Alhalabi, Obada, Armstrong, Christina, Castell Morley, Alexandra, Herzog, Wolfgang, Nikendei, Christoph   +6 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

International student mobility

The EHEA has prioritised international student mobility since the beginning of the Bologna Process, with recent efforts including the European Commission's endorsement of the "Europe on the Move" initiative aiming to increase learning mobility, address barriers, and promote sustainability.
openaire   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Supporting International Students in the Classroom [PDF]

The Universities in the UK aim to increase the numbers of International Students studying here, and this brings particular challenges for the teaching staff.
Cox, Yvette, Carl, Jenny
core  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Human immunodeficiency virus knowledge and stigma among medical students in Egypt: a national cross-sectional study

BMJ Open
Objectives To assess HIV knowledge, stigma and perceived adequacy of HIV curricular coverage among medical students in Egypt and to identify factors associated with HIV stigma.Design An online-based cross-sectional study.Setting Medical schools across ...
, Abdel-Hady El-Gilany, Yusof Mohamed Omar, Mohab Alsaid Saad, Olga Maria Eltarazy, Tasneem Deibes, Amr Ashraf Kamel, Mahmoud Yehia Basha, Mariam Mohamed Elsaeed, Esraa M Soliman, Sarah Youssef Atta, Mohamed Fathi, Basma Mohamed Nabil, Roaa Reziq Salem, Ayman Sameh Elhossiny Ali, Abdulkafi Mohammed Obad, Sara Hany Shehata, Mariam Baher Adly, Alyaa Ahmed Khalil, Mahmoud Sherif Mohamed, Youssef Samir Mohammed, Ali Haythem, Habiba Mahmoud Abo Hussin, Basant Hesham, Malak Gamal Mohamed, Monzer Mubarak Seedahmed, Alfred Edwar Ibrahem, Jana Ismael Sadek, Mohamed Habib, Rana Abdel-Hady Salem, Adham Hegazy, Zeyad Saber Mashaly, Mahmoud Anwar Swellam, Yasmin Mohamed Idrees Haiba, Mohamed NA Ibrahim   +34 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Can peritoneal dialysis be continued, as opposed to switching to HD, in end-stage renal disease patients with acute coronary syndrome with pulmonary edema?

Renal Failure
Background Managing acute coronary syndrome (ACS) with pulmonary edema is challenging in end-stage kidney disease (ESKD) patients on dialysis. While hemodialysis (HD) is often chosen for rapid fluid removal, peritoneal dialysis (PD) may better preserve ...
Yahn-Bor Chern, Yu-Ling Lin, Hsi-Hao Wang, Shih-Yuan Hung, Min-Yu Chang, Li-Chun Ho, Ching-Fang Wu, Hung-Hsiang Liou, Yi-Che Lee   +8 more
doaj   +1 more source