Results 101 to 110 of about 1,790,257 (326)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Internet addiction and psychological distress: Evidence from path analyses in Greek adolescents at different developmental stages

Ψυχολογία: το Περιοδικό της Ελληνικής Ψυχολογικής Εταιρείας
As internet use among adolescents increases, internet addiction has become a crucial public mental health issue, putting adolescents at risk of psychological distress.
Christina Parpoula, Vasiliki Yotsidi, Foivi-Eleni Adamopoulou   +2 more
doaj   +1 more source

Internet addiction and its determinants among medical students

Industrial Psychiatry Journal, 2015
Background: Exponential use of internet has resulted in internet addiction in recent times. Students are particularly at risk because of their unique personal, social, and academic needs.
Bhushan Chaudhari, Preethi Menon, Daniel Saldanha, Abhinav Tewari, Labhanya Bhattacharya   +4 more
doaj   +1 more source

Treatment outcomes using CBT-IA with Internet-addicted patients [PDF]

, 2013
Background and Aims: Internet Gaming Disorder, a subtype of Internet Addiction, is now classified in Section 3 of the DSM-5. Cognitive behavioral therapy (CBT) has been suggested in treating Internet addiction as this modality has been shown to be an ...
Young, Kimberly S.
core   +1 more source

Association of harsh parenting and maltreatment with internet addiction, and the mediating role of bullying and social support.

International Journal of Child Abuse & Neglect, 2021
Growing evidence has shown that exposure to harsh parenting and child maltreatment elevate the risk of Internet addiction in adolescence. Yet, limited research has examined the mechanisms underlying this association.
C. Lo, F. Ho, Clifton R. Emery, K. Chan, R. Wong, K. T. Tung, P. Ip   +6 more
semanticscholar   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Susceptibility of Shy Students to Internet Addiction: A Multiple Mediation Model Involving Chinese Middle-School Students

Frontiers in Psychology, 2019
Recent studies found that some personality traits (e.g., impulsivity, sensation seeking) are frequently related to Internet addiction. In line with previous studies, this study aimed to determine whether shy students readily develop Internet addiction ...
Yang Yu, Hong Sun, Fengqiang Gao
doaj   +1 more source

Burden of internet addiction, social anxiety and social phobia among University students, India

Journal of Family Medicine and Primary Care, 2020
Background: Social anxiety disorder (SAD) is a common mental health disorder affecting adolescents often associated with comorbidities like depression, suicide ideation and substance abuse.
Abhishek Jaiswal, Shubham Manchanda, Vaishali Gautam, Akhil D Goel, Jitender Aneja, Pankaja R Raghav   +5 more
doaj   +1 more source

Hubungan Antara Aktualisasi Diri Dengan Kecanduan Internet Pada Mahasiswa Universitas Muhammadiyah Surakarta [PDF]

, 2017
The existence of the Internet as a new communications media provides a variety of convenience in presenting information in real-time. People use the internet with various motifs. One motive of someone using the internet is to actualize themselves.
, Dr. Wiwien Dinar Pratisti, M.Si, Psi, Putri, Salma Larasati Suryama   +1 more
core