Results 281 to 290 of about 3,766,161 (380)

Activation of Kir4.1 Channels by 2‐D08 Promotes Myelin Repair in Multiple Sclerosis

Advanced Science, EarlyView.
Multiple sclerosis causes myelin loss and neurological dysfunction. This study shows that 2‐D08, a small molecule targeting Kir4.1 channels, promotes OPCs differentiation via FYN tyrosine kinase phosphorylation and the FYN/MYRF pathway. It significantly improves myelin repair and motor deficits in EAE mice and marmosets, highlighting its potential as a
Mingdong Liu, Shengyu Jin, Xin Fu, Chong Xie, Yi Chen, Liangtang Chang, Yongheng Fan, Donghua He, Xiaoqi Hong, Xi Shen, Xiaoli Zheng, Qiyue Wang, Dao Shi, Fangyuan Li, Daishun Ling, Yangtai Guan, Neng Gong, Xiaoping Tong   +17 more
wiley   +1 more source

EVMCSDLT: Electric vehicle mobile charging system using distributed ledger technology. [PDF]

MethodsX
Deshmukh N, Khairnar V, Vora D, Jovanovic A, Mouël FL.   +4 more
europepmc   +1 more source

De Novo Design of Specific Heterotrimeric Collagen‐Like Peptides via Genetic Algorithm

Advanced Science, EarlyView.
GRACE is a computational algorithm producing peptide sequences that will reliably fold into composition and registration‐controlled collagen‐like triple helices with user‐specified thermal stability. Additionally, GRACE allows users to specify the inclusion of biologically relevant (or other) sequences to automatically create tailored triple helices ...
Thi H. Bui, Oluwakamisi Adetunji, Carson C. Cole, Le Tracy Yu, Caroline M. Peterson, Jeffrey D. Hartgerink   +5 more
wiley   +1 more source

Drug Resistance Predictions Based on a Directed Flag Transformer

Advanced Science, EarlyView.
 CAPTURE, a deep learning framework combining structural and sequence data to predict drug‐resistant Mpro mutations, revealing that PAXLOVID use may be accelerating resistance—supporting real‐time viral surveillance and therapeutic design. Abstract The evolving SARS‐CoV‐2 virus threatens global public health, particularly with potential resistance to ...
Dong Chen, Gengzhuo Liu, Hongyan Du, Benjamin Jones, Junjie Wee, Rui Wang, Jiahui Chen, Jana Shen, Guo‐Wei Wei   +8 more
wiley   +1 more source

Effect of internet-delivered exposure therapy versus healthy lifestyle promotion for patients with persistent physical symptoms (SOMEX1): a randomized controlled trial with planned moderator analysis. [PDF]

Psychol Med
Hybelius J, Af Winklerfelt Hammarberg S, Salomonsson S, Wachtler C, Epstein M, Olsson A, Strand E, Söderström Winter L, Åkerlund T, Björkander D, Kosic A, Chahin G, Wallert J, Toth-Pal E, Nordin S, Axelsson E.   +15 more
europepmc   +1 more source

Factors Associated With Digital Addiction: Umbrella Review.

JMIR Ment Health
Han Y, Qiu J, Shi C, Huang S, Huang H, Wang X, Zhu S, Lu DL, Lu P, Zeng F.   +9 more
europepmc   +1 more source

Web-Based Education Program for Care Partners of People Living With Dementia (iGeriCare): Protocol for a Pilot Randomized Controlled Trial.

JMIR Res Protoc
Levinson AJ, Ayers S, Clark S, Woodburn R, Markle-Reid M, McKenna B, Oliver D, Papaioannou A, Siu H, Sztramko R.   +9 more
europepmc   +1 more source

Quantum secure direct communication: whispering with photons. [PDF]

Natl Sci Rev
Wang M, Long GL.
europepmc   +1 more source