Results 51 to 60 of about 295,552 (260)
Frontiers in Robotics and AI, 2022 Recent advances in deep learning have bolstered our ability to forecast the evolution of dynamical systems, but common neural networks do not adhere to physical laws, critical information that could lead to sounder state predictions.
Frances Zhu +3 more
doaj +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Interpretable Software Defect Prediction from Project Effort and Static Code Metrics
ComputersSoftware defect prediction models enable test managers to predict defect-prone modules and assist with delivering quality products. A test manager would be willing to identify the attributes that can influence defect prediction and should be able to ...
Susmita Haldar, Luiz Fernando Capretz
doaj +1 more source
Beyond Sparsity: Tree Regularization of Deep Models for Interpretability [PDF]
, 2017 The lack of interpretability remains a key barrier to the adoption of deep models in many applications. In this work, we explicitly regularize deep models so human users might step through the process behind their predictions in little time. Specifically,
Doshi-Velez, Finale +5 more
core +2 more sources
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Interpreting Scripture / Interpreting Law [PDF]
, 2012 Article published in the Michigan State Law Review.
openaire +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Frontiers in Cell and Developmental BiologyBackgroundThe T790M mutation is a significant mechanism of acquired resistance to EGFR-TKIs in non-small cell lung cancer (NSCLC). Its noninvasive detection in spinal metastases remains challenging due to tumour heterogeneity and limitations of current ...
Xiaoya Zhou +6 more
doaj +1 more source