Results 61 to 70 of about 244,685 (311)

Association Between Individualized Education for Kidney Replacement Therapy Modality Selection and Peritoneal Dialysis Initiation: A Cross‐Sectional Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Peritoneal dialysis (PD) is an established home‐based kidney replacement therapy (KRT), but its uptake remains low in Japan. We evaluated whether individualized education in a dedicated outpatient clinic was associated with the initiation of PD.
Yasuko Ito, Ryuichi Yoshimura, Takaki Yamauchi, Yuta Funakoshi, Hirotaka Sonoda, Seiji Kobayashi, Hiroyuki Terawaki, Takafumi Ito   +7 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Interpretability over Peano arithmetic [PDF]

, 1998
We investigate the modal logic of interpretability over Peano arithmetic (PA). Our main result is an extension of the arithmetical completeness theorem for the interpretability logic ILMω.
Stranneg\ue5rd, Claes, Strannegård, C.
core  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

MRI-based radiomics for noninvasive prediction of T790M resistance mutation in lung cancer spinal metastases: an exploratory study

Frontiers in Cell and Developmental Biology
BackgroundThe T790M mutation is a significant mechanism of acquired resistance to EGFR-TKIs in non-small cell lung cancer (NSCLC). Its noninvasive detection in spinal metastases remains challenging due to tumour heterogeneity and limitations of current ...
Xiaoya Zhou, Jiashi Zheng, Hua Ai, Chunna Yang, Jiahui Wang, Yiyao Sun, Lijun Jin   +6 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Enhancing Emergency Response in Road Accidents: A Severity Prediction Framework Using RF-RFE and Deep Learning Model

IEEE Access
Road accidents, particularly in urban areas, pose significant challenges due to their complexity and severe consequences. Rapid emergency response is crucial to mitigating their impact, especially for cases requiring urgent medical intervention.
Chaimaa Chaoura, Hajar Lazar, Zahi Jarir
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Research on Cavitation Fault Diagnosis of Axial Piston Pumps Based on Rough Set Attribute Weighted Convolutional Neural Networks

Sensors
Cavitation phenomenon in piston pumps not only causes vibration and noise but also leads to component damage. Conventional diagnostic methods suffer from low accuracy, while deep learning approaches lack interpretability.
Min Liu, Zhiqi Liu, Jinyuan Cui, Yigang Kong, Zhipeng Ma, Wenwen Jiang, Le Ma   +6 more
doaj   +1 more source

Toward Interpretable Machine Learning Models for Materials Discovery

Advanced Intelligent Systems, 2019
Machine learning (ML) and artificial intelligence (AI) methods for modeling useful materials properties are now important technologies for rational design and optimization of bespoke functional materials.
Paulius Mikulskis, Morgan R. Alexander, David Alan Winkler   +2 more
doaj   +1 more source