Results 81 to 90 of about 244,685 (311)

From Explanations to Interpretability and Back [PDF]

This chapter discusses connections between interpretability of machine learning and (scientific and mathematical) explanations, provides novel perspectives on interpretability, and highlights under-explored issues.
Räz, Tim
core  

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Graph-Based Radiomics Feature Extraction From 2D Retina Images

IEEE Access
Medical image analysis offers valuable visual support for clinical decision-making, yet the incorporation of quantitative data is essential for deeper diagnostic insight. The radiomics approach addresses this need by combining quantitative image analysis
Ofelio Jorreia, Nuno Goncalves, Rui Cortesao   +2 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Stroke detection in brain CT images using convolutional neural networks: model development, optimization and interpretability [PDF]

Stroke detection using medical imaging plays a crucial role in early diagnosis and treatment planning. In this study, we propose a Convolutional Neural Network (CNN)-based model for detecting strokes from brain Computed Tomography (CT) images.
Hasan, R., Mahmood, S., Sattar, U., Dattana, V., Abdi, H.   +4 more
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Interpretability of the European Heart Failure Self-care Behaviour scale

, 2017
Kim P Wagenaar,1 Berna DL Broekhuizen,1 Frans H Rutten,1 Anna Strömberg,2 Henk F van Stel,1 Arno W Hoes,1 Tiny Jaarsma2 1Julius Center for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht, the Netherlands; 2Department of
Wagenaar KP, Jaarsma T, Broekhuizen BD, van Stel HF, Rutten FH, Strömberg A, Hoes AW   +6 more
core  

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Interpretability of the correlation heatmap.

, 2022
Interpretability of the correlation heatmap.
Yutao Xue (12451975), Kaizhi Chen (14192740), Lianglong Chen (5715980), Huizhong Lin (14044381), Shangping Zhong (14192743)   +4 more
core   +1 more source