Results 141 to 150 of about 2,806,410 (297)

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui   +6 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

open access: yesMolecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son   +13 more
wiley   +1 more source

Cultural Competency in Research: A Practical Framework for Use by Researchers, Policymakers, Community Leads and Others When Working With People From Diverse Groups. [PDF]

open access: yesHealth Expect
Stepanova E   +14 more
europepmc   +1 more source

Interpreting Interpretative Errors

open access: yesZbornik radova Pravnog fakulteta u Splitu
This article examines the attribution of interpretative errors in judicial decision-making, a recurring yet under-theorised element of legal practice. It highlights how ideologies of legal interpretation and legal decision-making shape the criteria for evaluating interpretative correctness and critiques traditional dichotomies between axiological and ...
openaire   +2 more sources

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

open access: yesMolecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad   +12 more
wiley   +1 more source

Accuracy of junior doctor plain trauma X-ray interpretation: a systematic review and meta-analysis. [PDF]

open access: yesBMC Med Imaging
Acquah G   +6 more
europepmc   +1 more source

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