Results 141 to 150 of about 2,577,377 (248)

Comparative Effectiveness of Disease-Modifying Treatments in Double Seronegative Neuromyelitis Optica Spectrum Disorder. [PDF]

Neurol Neuroimmunol Neuroinflamm
Mahler JV, Vallejos GB, Mikami T, Bilodeau PA, Anderson M, Drosu N, Bobrowski-Khoury N, Silva GD, Solti M, Apóstolos-Pereira SL, Callegaro D, Leles Vieira de Souza B, Manzano GS, Vishnevetsky A, Gillani R, Pasquale O, Kim A, Vij R, Kister I, Gibbons EL, Jacob A, Huda S, Said Y, Krett JD, Sotirchos ES, Ramprasad M, Abboud H, Crelier VTC, Dos Santos G, Uawithya E, Siritho S, Sezen A, Altintas A, Gai F, Guo Y, Bhattacharyya S, Levy M, Matiello M.   +37 more
europepmc   +1 more source

Anticancer sensitivities and biological characteristics of HCT116 cells resistant to the selective poly(ADP‐ribose) glycohydrolase inhibitor

FEBS Open Bio, EarlyView.
We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley   +1 more source

Expert Consensus Approach to Developing Inpatient Common Data Elements for Neonatal Encephalopathy Research. [PDF]

Neurology
Peeples ES, Mietzsch U, Molloy EJ, Pilon B, Guez-Barber D, Soul J, Mohammad K, deVeber G, Chau V, Bonifacio SL, Craig AK, Afifi J, Sabir H, Groenendaal F, Shany E, Dizon MLV, Iwata O, Okulu E, Jermendy A, Boo NY, El-Dib M, Wintermark P, Newborn Brain Society Guidelines and Publications Committee.   +22 more
europepmc   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Optimizing Liver Transplant Allocation for Hepatocellular Carcinoma: Development and Validation of a Survival Benefit-Based Model. [PDF]

Clin Transplant
Liu H, Neckermann I, Mial-Anthony J, Elias C, Abdullah A, Sethi V, Kaltenmeier C, Rahman A, Ashwat E, Godwin P, Sabin S, Fokken T, Han S, Zhang X, Dharmayan S, Behari J, Celaj S, Molinari M.   +17 more
europepmc   +1 more source

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

FEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng, Souvik Datta, Derrick R. Samuelson   +2 more
wiley   +1 more source

Clinical amyloid and tau positron emission tomography imaging in Alzheimer's disease: image interpretation in the era of anti-amyloid therapies. [PDF]

Curr Opin Neurol
Mathoux G, Harput E, Peretti DE, Boccalini C, Garibotto V.   +4 more
europepmc   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Primary Alveolar Echinococcosis of the Kidney. [PDF]

Rev Soc Bras Med Trop
Esselmani H, Hnini R, Silva E, Najimi M, Merzouki M.   +4 more
europepmc   +1 more source