Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Ultrasound Assessment of the Anterolateral Ligament of the Knee: A Narrative Review of Current Evidence, Interpretative Limitations, and Clinical Context. [PDF]
Diagnostics (Basel)Niewiadomy P, Szuścik-Niewiadomy K.
europepmc +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Commentary: Methodological considerations in the interpretation of evidence on cannabis-based medicines for chronic neuropathic pain. [PDF]
J Cannabis ResBriques W +2 more
europepmc +1 more source
Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae
FEBS Open Bio, EarlyView.Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj +3 more
wiley +1 more source
منهج الإمام البیضاوی فی اختیاراته و ترجیحاته في التفسیر: دراسة تحلیلية وصفية
البصيرةThis research delves into the methodology and approach of Imam Al-Baydawi in his interpretative preferences within Tafsir. Focused on the theoretical and practical aspects, it aims to unravel the nuanced choices made by this renowned scholar.
Mehmood Hasan, Musaab Iftikhar Durrani
doaj
Methodological and Interpretative Considerations in 'Exploring the Patient Engagement in the Healthcare Decision-Making Process and Its Association With Patients' Satisfaction'. [PDF]
Nurs OpenZhang M, Ke H.
europepmc +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
Which front-of-pack nutritional label (FOPNL) is most effective in promoting healthier dietary choices? An experimental study in Indonesia. [PDF]
BMJ Public HealthColozza D +8 more
europepmc +1 more source
PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines
FEBS Open Bio, EarlyView.Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart +7 more
wiley +1 more source