Results 91 to 100 of about 33,459 (265)
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Hard and Soft Law in the European Union: The case of Social policy and the Open Method of Coordination [PDF]
The European integrative experiment rests on a dynamic equilibrium of intergovernmental and supranational features of the regulatory framework of the European Union.
Luca Barani
core
Screening for lung cancer: A systematic review of overdiagnosis and its implications
Molecular Oncology, EarlyView.Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz +12 more
wiley +1 more source
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Molecular Oncology, EarlyView.A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He +8 more
wiley +1 more source
Heidegger’s Distinction between Scientific and Philosophical Judgments [PDF]
, 2007 Some commentators, such as Jürgen Habermas, think Martin Heidegger is guilty of a performative contradiction, because he uses judgments to situate judgments in a non-judicative context.
Engelland, Chad
core +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Judicial Checklist of Country of Origin Information and Due Process in the Light of EU (Fundamental) Law [PDF]
The author identifies an important trend in deliberation of international standards of good practice in protection of refugees based on ad hoc networking and cooperation between judges and other experts under the auspices of the IARLJ.
Zalar, Boštjan
core
Contrasting Classic, Straussian, and Constructivist Grounded Theory: Methodological and Philosophical Conflicts [PDF]
, 2015 Grounded Theory (GT) is an innovative research methodology, consisting of three prevailing traditions: Classic, Straussian, and Constructivist GT. Despite arising from the same root, and sharing a number of the original methodological techniques, Classic,
Fourie, Robert, Kenny, Méabh
core +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source