Results 91 to 100 of about 1,139 (284)
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
De kwaliteit van milieurichtlijnen
, 2010 This research concerns the implementation of European environmental directives in national law, with a focus on transposition. The research question is what role the directives themselves have in the occurrence of implementation problems in the Member ...
UU LEG Research LAW Omgevingsrecht (Environmental Law) +2 more
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Immigration and labour policies: paradoxes of the European Union
, 2018 This paper analyses the theme of migrant workers in the context of EU common policy post-Lisbon. After describing the evolution of the common EU policy, it is argued that the structural answer to the issue of migrant workers requires an inclusive ...
Calafà, Laura, Laura Calafà
core +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
I rapporti negoziali degli enti di gestione dei porti e il Codice dei contratti pubblici
, 2018 The Managing Bodies of Seaports' Contractual Activity and the Codice dei Contratti Pubblici. This paper analyses the area of subjection of the seaports managing bodies' contractual activity to the EU directives on public procurement, transposed by the ...
Ragusa, Marco
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Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
, 2019 The chapter focuses on the managing bodies of seaports' contractual activity under the EU directives on public procurement and the Codice dei contratti pubblici.
RAGUSA
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CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
, 2013 The aim of this work is the in-depth examination of the European prohibition of waiver of the rights conferred on the consumer by the EU directives pertaining b2c “in distance” and “off-premises” contracts, as well as by the directives concerning the ...
BENINI, Giulia
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