Results 171 to 180 of about 33,459 (265)

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

FEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng, Souvik Datta, Derrick R. Samuelson   +2 more
wiley   +1 more source

Mental Health Nurses' Enforcement of Involuntary Care in Inpatient Settings: A Meta-Ethnography. [PDF]

Int J Ment Health Nurs
Molloy L, Beckett P, Chidarikire S, Cutler N, Isobel S, Murphy G, Zugai J.   +6 more
europepmc   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

Improving specialist palliative care discharges from hospitals and hospices to community settings: a qualitative interview study of the communication experiences of patients, carers, and primary care professionals. [PDF]

BMC Palliat Care
Weetman K, Grimley C, Bailey C, Bernstein CJ, Dale J, Fitch A, Mitchell S, Tiwana R, MacArtney JI.   +8 more
europepmc   +1 more source

Analysis of European law as regard to access of detained persons to the law and to court [PDF]

, 2019
Ciuffoletti, Sofia, Claeys, Jasmien, de Suremain, Hugues, Eechaudt, Vincent, Ranalli, Daniela, Vander Beken, Tom   +5 more
core   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Strengthening the use of regulatory policy measures for prevention of NCDs in Europe through the JA PreventNCD project. [PDF]

Scand J Public Health
Helleve A, Gregório MJ, Bergsvik D, Kocbach Bølling A, De Cosmi V, Fras N, Gabrijelčič Blenkuš M, Gallopel-Morvan K, Haug LS, Karlsson T, Lindeman M, Bergmann Madsen B, Silano M, Siponen T, Teyssier S, Vedøy TF, Vin K, Øvrevik J.   +17 more
europepmc   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

A Mixed-Methods Systematic Review on the Impacts and Implementation of Collaborative Electronic Documentation on Nurse-Patient Relationship. [PDF]

Comput Inform Nurs
Iwuchukwu G, Anttila M, Lantta T, Varpula J, Ameel M.   +4 more
europepmc   +1 more source