Results 71 to 80 of about 26,187 (263)

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Results in physics education research as lenses for analyzing textbooks, recognizing critical details and fostering thinking. The case of teaching/learning special relativity

Revista de Enseñanza de la Física, 2014
The teaching of special relativity, both at the secondary school level and at the university level, is still strongly influenced by the approach designed by Resnick in 1968.
Olivia Levrini
doaj  

Mindreading, introspezione e metacognizione: implicazioni per la neuropsichiatria cognitiva

Rivista Internazionale di Filosofia e Psicologia, 2013
Mindreading, Introspection, and Metacognition: Implications for Cognitive Neuropsychiatry - The aim of this article is to draw sharp boundaries between the concepts of mindreading, introspection and metacognition in order to rectify some common ...
Rossella Guerini, Massimo Marraffa
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

ppropriation of scientific discourse by protestant biology students: the contribution of Bakhtin's language theory to educational research and culture [PDF]

Investigações em Ensino de Ciências, 2006
Studies about the relations between classroom discourse interactions and processes of teaching and learning show that science learning is related to a process structured by speech genres and ways of establishing semantic links between events, objects ...
Claudia Sepulveda, Charbel Niño El-Hani
doaj  

L’orientation épistémique de la lecture Selon comme nous poserons le problème nous n’enseignerons pas la même chose

Repères, 2012
When young readers are asked about their personal and academic reading practice, one of their prevailing representations belongs to the knowledge paradigm. Their main reading motivation is to gain new knowledge.
Marie-Cécile Guernier
doaj   +1 more source

Researching strategy practices: a genealogical social theory perspective [PDF]

, 2009
This paper explores the meaning and significance of the term `social practice' and its relation to strategy-as-practice research from the perspective of social theory.
Chia, Robert C. H., Chia, R., Chia, Robert, Robert Chia, Rasche, Andreas, Andreas Rasche, Rasche, A.   +6 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Data integration levels. Between scientific research and professional practice in clinical psychology

Current Issues in Personality Psychology, 2017
The article deals with the question of linking two spheres: research practice (psychology as empirical science) and professional practice1 (psychology as a scientifically and ethically meaningful practical action: diagnostic and therapeutic).
Jerzy M. Brzeziński
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source