Results 91 to 100 of about 26,187 (263)
Revista Eletrônica do Curso de Direito da UFSM, 2018 In a context of relativization the division between creation and application of the law, the article aims to analyze, under the analytical and conceptual perspective of philosophy, the problem of the degree of interpretative freedom, the (in ...
Loiane Prado Verbicaro
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Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
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Subjectivity in the illness process and dialogue as a facilitator of new subjective senses [PDF]
Estudos de Psicologia (Campinas)Objective The article aimed to study the subjective configurations of a person diagnosed with cancer based on the theoretical framework of the Theory of Subjectivity in a Historical-Cultural perspective as proposed by González Rey.
Manoel Vitor Noleto +1 more
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Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Response to The Lost Thing: Notes from a Secondary Classroom
CLELEjournal, 2013 This paper discusses students’ responses to the picturebook The Lost Thing (Tan, 2000) and its film (2010). It describes a small-scale project in a secondary school in Portugal, which involved 16-18 year-old students, learning English as a foreign ...
Sandie Mourão
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, 2014 Mindfulness-based interventions are reported as being efficacious treatments for a variety of psychological and somatic conditions. However, concerns have arisen relating to how mindfulness is operationalized in mindfulness-based interventions and ...
Van Gordon, W, Shonin, E, Griffiths, MD
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Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
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Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
The Futures of Qualitative Social Research
Forum: Qualitative Social Research, 2014 In this contribution I begin by reviewing past views on the future of qualitative social research. In different ways, all of these views give the same account of a problematic present state which must be overcome by following their own particular ...
Reiner Keller
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