Results 111 to 120 of about 26,187 (263)

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Directival Theory of Meaning Resurrected

Studia Semiotyczne, 2019
DOI: http://doi.org/10.26333/sts.xxxi1.03 The first aim of this paper is to remind the reader of a very original theory of meaning which in many aspects has not been surpassed by subsequent theories.
Paweł Grabarczyk
doaj  

Oltre il “paradosso di genere”: l’identità di genere come “schema culturale” e “risorsa simbolica” nell’era delle singolarità

SocietàMutamentoPolitica: Rivista Italiana di Sociologia
The analysis of the so-called gender paradox represents the starting point of a theoretical-interpretative framework which, through a structuralist analysis of gender identity, intends to introduce understanding criteria capable of shedding new light on ...
Silvia Cervia
doaj   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Davida Bohma teoria zmiennych ukrytych

Zagadnienia Filozoficzne w Nauce, 2009
One of the most important interpretative problems of quantum mechanics concerns the so called hidden variables. Sometimes it is said that the Bell's theorem falsifies theories of such variables, but in fact, it falsifies only local ones. This paper deals
Tadeusz Pabjan
doaj  

“I Don’t Know if They Really Hated Us or if It Was for Fun”: Memories of Anti-Jewish Violence Perpetrated by Students of the Catholic University of Lublin in Oral Histories from the Grodzka Gate – NN Theatre Centre

Studia Judaica
This article explores the narratives describing the interactions between students of the Catholic University of Lublin and the local Jewish population.
Magdalena Dziaczkowska
doaj   +1 more source

Systems Theory in Immunology

, 1979
This volume collects the contributions presented at the "Working Conference on System Theory in Immunology", held in Rome, May 1978. The aim of the Conference was to bring together immunologists on one side and experts in system theory and applied ...
Bruni, Carlo, Doria, Gino, G. DORIA, Koch, Giorgio, Strom, Roberto   +4 more
core   +1 more source