Results 101 to 110 of about 26,187 (263)
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Social InclusionThis article examines how Norwegian universities implement gender equality and diversity policies through a Bakhtinian dialogical lens. Using document analysis of action plans from four major universities and interviews with 19 department heads and ...
Vivian Anette Lagesen +3 more
doaj +1 more source
, 2022 International audienceThis paper focuses on the reconstruction of generalization processes in interactions. By coordinating different theories, a way to reconstruct these processes by means of interpretative research is presented.
Meyer, Michael, Körner, Christoph
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Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
The experience of humour in Asperger’s syndrome [PDF]
, 2010 A Thesis submitted in fulfilment of the requirements of the University of Wolverhampton for the degree of Doctor of Counselling Psychology.This study investigated the experience of humour of people with Asperger’s syndrome.
Ruggeri, Susan
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Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Interpretative phenomenological analysis: theory, method and research
, 2009 Interpretative phenomenological analysis (IPA) is an increasingly popular approach to qualitative inquiry. This handy text covers its theoretical foundations and provides a detailed guide to conducting IPA research.
Smith, JA +6 more
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MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
What are the experiences of those attending a self help hearing voices group: an interpretative phenomenological approach [PDF]
, 2011 Introduction: Self-help Hearing Voices Groups (HVG) have grown in popularity here in the UK, and internationally, since the 1980s. Despite research into the potential benefits of attending self-help groups for other mental health problems, little is ...
Hendry, Gemma Louise
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Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source