Results 121 to 130 of about 26,187 (263)

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Revisiting the role of the grounded theory research methodology in the accounting Information systems [PDF]

open access: yes, 2012
The aim of this paper is to explore the role of grounded theory (GT) as a research method in the accounting information systems. The GT research method can able the GT researcher to generate a rigour theory.
El Tawy, N, Abdel-Kader, M
core  

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel   +4 more
wiley   +1 more source

Interpretations of the Classic: The Theory of Wages [PDF]

open access: yes
The well-known enduring controversy on the interpretation of Ricardo's wage theory, and by implication on classical wage theory, has undoubtedly been fuelled by the existence of some inconsistencies in Ricardo's writings.
Antonella Stirati
core  

The effortful citizen: discursive social psychology and welfare reform

open access: yes, 2009
The present study applies a broadly discursive approach to the representation of welfare reform and unemployment through an analysis of the deployment of an interpretative repertoire of effortfulness in posts to an internet discussion forum. It is argued
Stephen Gibson   +2 more
core   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

open access: yesFEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik   +6 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

open access: yesFEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Theory That Matters What Practice After Theory

open access: yes
"Covering an impressive scope of subjects in literary and cultural theory, from Freud, Heidegger and Barthes to Fish, Rorty and Bhabha, Theory That Matters offers a welcome up-to-date assessment of the state of the discipline.
Bartczak, Kacper., Myk, Małgorzata.
core  

Exploring prostituted women's experiences of a South African exit intervention: an interpretative phenomenological analysis

open access: yes, 2011
Prostitution is the oldest form of oppression. Many prostituted women in South Africa wish to exit sex work, but are unable to because they have no other means of earning money.
Heiberg, Tessa
core  

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