Results 31 to 40 of about 3,332 (292)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

The second coming of Van Gennep among the Serbs A contribution to the history of Serbian ethnology/anthropology in the final quarter of the XX century

Etnoantropološki Problemi, 2016
Emergence of the Serbian translation of Van Gennep’s major work "The Rites of Passage" initiates recapitalization of the influence theory of rites of passage had on studies of customs in Serbian scholarship.
Ivan Kovačević
doaj  

“If they can get it right why don’t I?” Year Ten students’ experiences of studying in the free school meal achievement gap an Interpretative Phenomenological Analysis. [PDF]

, 2013
This study aims to explore how Year Ten students make sense of the experience of studying and achieving in academic subjects. Purposive homogenous sampling was used to select Year Ten students from the same school, eligible for free school meals and ...
Willott, Claire
core  

Translation of doublespeak from relevance theory perspective: More flexible possibilities

, 2022
The present study is related to the field of translation and aims to analyse the translation of English doublespeak into Arabic from relevance theory perspective.
BENLAKDAR, Meriam
core  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Trans-Translation and Risk Management: The Nigerian Perspective

Translation Studies: Theory and Practice
This paper sets out to explore the various risks involved in translating, and how these risks can be overcome to achieve the ultimate goal of translation.
Muhammad Zayyanu Zaki, Anthony Chunononye Nwanjoku, Atiku Sani   +2 more
doaj   +1 more source

An exploration of the lived experience of progressive cerebellar Ataxia: An interpretative phenomenological analysis [PDF]

, 2012
This thesis was submitted for the degree of Doctor of Philosophy and was awarded by Brunel UniversityBackground and Purpose: Progressive cerebellar ataxia is a rare neurological condition characterised by uncoordinated movement, and impaired speech ...
Cassidy, Elizabeth Emma
core  

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Translation of the absurdist literature as an example of cultural transfer (“Cases” by Daniil Kharms in Korean translations)

Слово.ру: балтийский акцент
The article explores the semiotic aspects of the theory of cultural transfer, translation, and (non)translation, with a specific focus on the translator's comment.
Gazinur G. Gizdatov
doaj   +1 more source