Results 31 to 40 of about 77,843 (262)
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Sich (k)einen Namen machen: Die Židovská jména der Honza K. [PDF]
Slovo a Smysl, 2017 Even though the anthology Jewish Names, often called the beginning of Czech alternative culture, was published in 1995, several central questions concerning this seminal collection from the early 1950s remain unclear: Who initiated it, when was it ...
Natascha Drubek
doaj
Teaching Mathematics to First-year Foreign Students of Technical University
Высшее образование в России, 2018 The article presents the results of a research aimed at the investigation of the causes of the extremely low academic performance of the first-year foreign students of the Ukhta State Technical University in the discipline “Mathematics”. This category of
O. M. Prudnikova
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Вестник Тамбовского университета. Серия: Гуманитарные науки, 2016 The results of the PE teachers’ opinion about peculiarities and the implementation of All-Russian health and fitness complex “Ready for Labour and Defense” basing on the example of Belgorod region are presented.
Andrey Vitalevich Skabuk
doaj +1 more source
De la négation à la focalisation : le cas du morphème « du » en wolof et ses connexions émotionnelles [PDF]
Revue Roumaine d’Etudes Francophones, 2023 In Wolof, negation can be formally identified by the use of negative markers depending on the completed or not completed process. However, among these markers, there is a du negation morpheme which can lead to a double focus in the statement, but ...
Adjaratou O. SALL
doaj
Interrogation models in contemporary criminal procedure [PDF]
Zbornik Radova: Pravni Fakultet u Novom Sadu, 2011 The paper is divided onto four major parts. In the introductory part the author states that personal evidence (statements of whiteness, suspect, accused, convicted and expert) play still a very important role in collecting evidence in criminal procedure,
Feješ Ištvan
doaj +1 more source