Results 41 to 50 of about 3,159 (306)
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
The Prosody of French Interrogatives
, 2007 Our aim is the study of the intonation of interrogatives in French. Interrogatives refer to a clause type, defined independently of illocutionary forces or actual speech act values in context.
Beyssade, Claire
core +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
The relationship between demonstratives and interrogatives
, 2003 This paper examines two types of expressions that seem to exist in all languages, demonstratives and interrogatives. Based on a representative sample of 100 languages it is shown that demonstratives and interrogatives have some striking features in ...
Diessel, Holger +1 more
core +1 more source
Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
IF IT WALKS LIKE A PROVERB AND TALKS LIKE A QUESTION
Proverbium, 2013 Although a small number of question-form phrases have been included in standard proverb dictionaries or have been proposed for inclusion in future dictionaries, many of these phrases, although fixed in form, lack the truth-statement function that ...
Heather A. Haas
doaj
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Glossa, 2018 Tactile sign languages used by Deafblind signers are most often acquired by signers competent in a visual sign language who can no longer rely on the grammatical system of the visual language as it is, since some of its features are lost due to the loss ...
Alessandra Checchetto +3 more
doaj +2 more sources
High and low uniqueness in singular wh-interrogatives
, 2021 While simple singular wh-interrogatives carry a uniqueness presupposition, this is not so when they contain possibility modals. Hirsch & Schwarz (2019) account for this contrast by assuming (i) that questions can have multiple maximally informative ...
Kobayashi, Filipe Hisao +1 more
core +1 more source