Results 51 to 60 of about 27,854 (318)

Lessons from overtly-headed exclamatives in Spanish varieties

Isogloss
Inverting wh-exclamative sentences with an overt complementizer in languages like Spanish pose a serious challenge to traditional accounts of obligatory subject-verb inversion.
Julio Villa-García
doaj   +1 more source

Question/answer congruence and the semantics of wh-phrases [PDF]

, 2013
This paper is about the semantics of wh-phrases. It is argued that wh-phrases should not be analyzed as indefinites as, for example, Karttunen (1977) and many others have done, but as functional expressions with an indefinite core -their function being ...
Reich, Ingo
core  

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

The intonation of information-seeking absolute interrogatives in Madrid Spanish

Estudios de Fonética Experimental, 2020
Romera and Elordieta (2019) and Elordieta and Romera (2020) reported that most information-seeking absolute interrogatives in the variety of Spanish spoken in the Basque Country have a rising-falling circumflex final contour.
Gorka Elordieta, Magdalena Romera
doaj  

The language instinct in extreme circumstances: The transition to tactile Italian Sign Language (LISt) by Deafblind signers

Glossa, 2018
Tactile sign languages used by Deafblind signers are most often acquired by signers competent in a visual sign language who can no longer rely on the grammatical system of the visual language as it is, since some of its features are lost due to the loss ...
Alessandra Checchetto, Carlo Cecchetto, Carlo Geraci, Sandro Zucchi   +3 more
doaj   +2 more sources

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Les mouvements de tête dans les interrogatives en langue des signes québécoise [PDF]

, 1991
Parmi les trois procédés par lesquels les langues marquent les interrogatives, deux concernent les mots ou les signes (particules interrogatives et ordre des constituants) et un se superpose aux mots ou aux signes (intonation/comportement non manuel ...
Boulanger, Johanne, Desrosiers, Jules, Dubuisson, Colette, Lelièvre, Linda   +3 more
core   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

IF IT WALKS LIKE A PROVERB AND TALKS LIKE A QUESTION

Proverbium, 2013
Although a small number of question-form phrases have been included in standard proverb dictionaries or have been proposed for inclusion in future dictionaries, many of these phrases, although fixed in form, lack the truth-statement function that ...
Heather A. Haas
doaj