Results 71 to 80 of about 27,854 (318)

Cognitive constraints and island effects [PDF]

open access: yes, 2010
Competence-based theories of island effects play a central role in generative grammar, yet the graded nature of many syntactic islands has never been properly accounted for.
Ivan A. Sag,, Philip Hofmeister,
core   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

Managing the Moral Implications of Advice in Informal Interaction [PDF]

open access: yes, 2013
What does advice giving look like among family members? Most conversation analytic research on advice has been in institutional settings, which constrain what speakers can do.
Hepburn, A, Shaw, C
core   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

open access: yesMolecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix   +13 more
wiley   +1 more source

Variation in interrogative adverbials: 'cuán', 'qué tan', 'cómo de','lo que' and 'lo'+adj./adv.+'que'

open access: yesBorealis: An International Journal of Hispanic Linguistics, 2019
Cuán, qué tan, and cómo de are used to modify adverbs and adjectives in interrogatives. They are also used in embedded clauses along with lo que. Instances of these expressions were extracted from the Corpus del Español.
David Ellingson Eddington
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Syntactic variation and diglossia in French [PDF]

open access: yes, 2011
The present article addresses syntactic variation within French, and is an example of a relatively recent shift in attitude towards variation in this language.
Rowlett, PA
core  

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

open access: yesMolecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon   +4 more
wiley   +1 more source

Review of the book Deaf around the World: The impact of language / ed. by Mathur & Napoli [PDF]

open access: yes, 2012
(first paragraph) Since its advent half a century ago, the field of sign language linguistics has had close ties to education and the empowerment of deaf communities, a union that is fittingly celebrated by Deaf around the world: The impact of language ...
de Vos, Connie, Palfreyman, Nick
core   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

open access: yesFEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth   +6 more
wiley   +1 more source

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