Results 31 to 40 of about 71,802 (256)

Impact of the acute national blood culture bottle shortage on the two-set blood culture rate in a single center in Japan: Insights from an interrupted time-series analysis

Infection Prevention in Practice
Summary: Background: In 2024, a worldwide shortage of blood culture bottles prompted efforts to mitigate its impact, including strategies to reduce blood culture orders.
Tetsuji Morishita, Masao Kuwabara, Masayoshi Monji, Shin Lee, Makoto Hayashi, Hisashi Tsurumi, Hidetoshi Matsunami   +6 more
doaj   +1 more source

Hospitalization of mild cases of community-acquired pneumonia decreased more than severe cases during the COVID-19 pandemic

International Journal of Infectious Diseases, 2021
Objective: The coronavirus disease 2019 (COVID-19) pandemic has affected all healthcare systems. This study aimed to assess the impact of the COVID-19 pandemic on the number and severity of cases of community-acquired pneumonia (CAP) in Japan.
Hiroyuki Nagano, Daisuke Takada, Jung-ho Shin, Tetsuji Morishita, Susumu Kunisawa, Yuichi Imanaka   +5 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Handling Missing Values in Interrupted Time Series Analysis of Longitudinal Individual-Level Data

Clinical Epidemiology, 2020
Juan Carlos Bazo-Alvarez,1,2 Tim P Morris,3 Tra My Pham,3 James R Carpenter,3,4 Irene Petersen1,5 1Research Department of Primary Care and Population Health, University College London (UCL), London, UK; 2Instituto de Investigación, Universidad Cat&
Bazo-Alvarez JC, Morris TP, Pham TM, Carpenter JR, Petersen I   +4 more
doaj  

The effect of Share 35 on biliary complications: An interrupted time series analysis [PDF]

American Journal of Transplantation, 2019
The purpose of the Share 35 allocation policy was to improve liver transplant waitlist mortality, targeting high MELD waitlisted patients. However, policy changes may also have unintended consequences that must be balanced with the primary desired outcome. We performed an interrupted time series assessing the impact of Share 35 on biliary complications
J N, Fleming, D J, Taber, D, Axelrod, K D, Chavin   +3 more
openaire   +2 more sources

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

Scottish Keep Well health check programme: an interrupted time series analysis [PDF]

Journal of Epidemiology and Community Health, 2016
Background Effective interventions are available to reduce cardiovascular risk. Recently, health check programmes have been implemented to target those at high risk of cardiovascular disease (CVD), but there is much debate whether these are likely to be effective at population level.
Geue, Claudia, Lewsey, James D., MacKay, Daniel F., Antony, Grace, Fischbacher, Colin M., Muirie, Jill, McCartney, Gerard   +6 more
openaire   +3 more sources

Digital Cognitive Phenotyping for Differential Diagnosis and Monitoring in Neurological Conditions

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To assess the utility, accessibility, and equivalence to supervised scales of online cognitive assessment in older individuals with cognitive impairment. Methods Patients with Alzheimer's disease (AD, n = 31), idiopathic normal pressure hydrocephalus (iNPH, n = 26), and traumatic brain injury (TBI, n = 23) completed online cognitive ...
Martina Del Giovane, Valentina Giunchiglia, Michael C. B. David, Magdalena A. Kolanko, William R. Trender, Peter J. Hellyer, Harmeena Kaur, David J. Sharp, Christopher Carswell, Paresh A. Malhotra, Adam Hampshire   +10 more
wiley   +1 more source

Effect of the COVID‐19 pandemic on the frequency of emergency department visits in Portugal: An interrupted time series analysis until July 2021

Journal of the American College of Emergency Physicians Open, 2023
Objectives This study aims to evaluate the effect of the COVID‐19 pandemic on the frequency of emergency department (ED) visits in Portugal between March 2020 and July 2021.
Sílvia Lopes, Patrícia Soares, Joana Santos Sousa, João Victor Rocha, Paulo Boto, Rui Santana   +5 more
doaj   +1 more source

Continuity of community-based healthcare provision during COVID-19: a multicountry interrupted time series analysis

BMJ Open, 2022
Background Pandemics often precipitate declines in essential health service utilisation, which can ultimately kill more people than the disease outbreak itself.
Caroline Whidden, Daniel Palazuelos, Madeleine Ballard, Jane Yang, Molly Christiansen, Carey Westgate, Amanda Yembrick, Diego Lassala, Fabien Munyaneza, Helen E Olsen, Anoushka Millear, Dianne Thakura, Afra Nuwasiima, Daniele J Ressler, Wycliffe Okoth Omwanda   +14 more
doaj   +1 more source