Results 31 to 40 of about 74,457 (256)

Hospitalization of mild cases of community-acquired pneumonia decreased more than severe cases during the COVID-19 pandemic

International Journal of Infectious Diseases, 2021
Objective: The coronavirus disease 2019 (COVID-19) pandemic has affected all healthcare systems. This study aimed to assess the impact of the COVID-19 pandemic on the number and severity of cases of community-acquired pneumonia (CAP) in Japan.
Hiroyuki Nagano, Daisuke Takada, Jung-ho Shin, Tetsuji Morishita, Susumu Kunisawa, Yuichi Imanaka   +5 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Handling Missing Values in Interrupted Time Series Analysis of Longitudinal Individual-Level Data

Clinical Epidemiology, 2020
Juan Carlos Bazo-Alvarez,1,2 Tim P Morris,3 Tra My Pham,3 James R Carpenter,3,4 Irene Petersen1,5 1Research Department of Primary Care and Population Health, University College London (UCL), London, UK; 2Instituto de Investigación, Universidad Cat&
Bazo-Alvarez JC, Morris TP, Pham TM, Carpenter JR, Petersen I   +4 more
doaj  

The effect of Share 35 on biliary complications: An interrupted time series analysis [PDF]

American Journal of Transplantation, 2019
The purpose of the Share 35 allocation policy was to improve liver transplant waitlist mortality, targeting high MELD waitlisted patients. However, policy changes may also have unintended consequences that must be balanced with the primary desired outcome. We performed an interrupted time series assessing the impact of Share 35 on biliary complications
J N, Fleming, D J, Taber, D, Axelrod, K D, Chavin   +3 more
openaire   +2 more sources

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

ASSESSMENT OF THE IMPACT OF THE COVID-19 PANDEMIC ON HIV INDICATORS IN BRAZIL: A TIME-SERIES ANALYSIS

Brazilian Journal of Infectious Diseases
Introduction: In March 2020, the World Health Organization declared the onset of the COVID-19 pandemic caused by SARS-CoV-2. This global crisis overwhelmed healthcare systems, including in Brazil, adversely affecting the control of several infectious ...
Beatriz Sousa-Peres, Sarah Maiche, Klauss Villalva-Serra, Artur T.L. Queiroz, Moreno M.S. Rodrigues, Bruno B. Andrade, Mariana Araújo-Pereira   +6 more
doaj   +1 more source

Effect of the COVID‐19 pandemic on the frequency of emergency department visits in Portugal: An interrupted time series analysis until July 2021

Journal of the American College of Emergency Physicians Open, 2023
Objectives This study aims to evaluate the effect of the COVID‐19 pandemic on the frequency of emergency department (ED) visits in Portugal between March 2020 and July 2021.
Sílvia Lopes, Patrícia Soares, Joana Santos Sousa, João Victor Rocha, Paulo Boto, Rui Santana   +5 more
doaj   +1 more source

Immediate versus sustained effects: interrupted time series analysis of a tailored intervention [PDF]

Implementation Science, 2013
Abstract Background Detailed intervention descriptions and robust evaluations that test intervention impact—and explore reasons for impact—are an essential part of progressing implementation science. Time series designs enable the impact and sustainability of intervention effects to be tested.
Hanbury, A, Farley, K, Thompson, C, Wilson, PM, Chambers, D, Holmes, H   +5 more
openaire   +3 more sources