Results 41 to 50 of about 467,024 (301)

The effects of new urban motorway infrastructure on road traffic accidents in the local area: a retrospective longitudinal study in Scotland [PDF]

, 2016
Background: The M74 motorway extension, Glasgow, opened in June 2011. One justification for construction was an expectation that it would reduce road traffic accidents (RTAs) on local non-motorway roads.
Humphreys, David K., Mackay, Daniel F., Mitchell, Richard, Ogilvie, David, Olsen, Jonathan R.   +4 more
core   +2 more sources

Editorial Commentary: Quasi-Experimental and Interrupted Time-Series Design [PDF]

Journal of the Pediatric Infectious Diseases Society, 2012
In this issue of the Journal of the Pediatric Infectious Diseases Society, Newland et al use a quasi-experimental study design. This study design, also known as a nonrandomized, postintervention design, is beneficial in infectious disease studies where complete control over the allocation and/or the timing of the intervention is not possible or is not ...
Lilliam, Ambroggio, Michael J, Smith, Samir S, Shah   +2 more
openaire   +2 more sources

Sirolimus for Extracranial Arteriovenous Malformations: A Scoping Review of the Evidence in Syndromic and Non‐Syndromic Cases

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Arteriovenous malformations (AVMs) are rare, high‐flow, vascular anomalies that can occur either sporadically or as part of a genetic syndrome. AVMs can progress with serious morbidity and even mortality if left unchecked. Sirolimus is an mTOR inhibitor that is effective in low‐flow vascular malformations; however, its role in AVMs is unclear.
Will Swansson, Ingrid Winship, Gary Hammerschlag, Laura Scardamaglia   +3 more
wiley   +1 more source

Are tobacco control policies effective? Interrupted time series analysis of routine tobacco surveillance ‎data: opportunities and challenges ‎

Tobacco Prevention and Cessation, 2019
Introduction Tobacco control policies intend to impact long-term indicators of population health via ‎reducing the prevalence of tobacco use (POTU). Interrupted time series (ITS) analysis gives opportunities ‎in analyzing routinely collected longitudinal
Tatiana Andreeva
doaj   +1 more source

Effect of a tailored sepsis treatment protocol on patient outcomes in the Tikur Anbessa Specialized Hospital, Ethiopia: results of an interrupted time series analysis

Implementation Science, 2022
Background Despite improvement, sepsis mortality rates remain high, with an estimated 11 million sepsis-related deaths globally in 2017 (Rudd et. al, Lancet 395:200-211, 2020).
Lisa M. Puchalski Ritchie, Lemlem Beza, Finot Debebe, Andualem Wubetie, Kathleen Gamble, Gerald Lebovic, Sharon E. Straus, Tigist Zewdu, Aklilu Azazh, Cheryl Hunchak, Megan Landes, Dawit Kebebe Huluka   +11 more
doaj   +1 more source

Delayed Diagnosis and Treatment of Cancer Patients During the COVID-19 Pandemic in Henan, China: An Interrupted Time Series Analysis

Frontiers in Public Health, 2022
ObjectiveTo investigate the possible impact of lockdown policies on the diagnosis and treatment of cancer patients in Henan, China.Design, Setting, and ParticipantsWe collected data from the Henan Cancer Hospital, affiliated with Zhengzhou University ...
Changpeng Liu, Heng Piao, Tao Zhang, Dongjian Yang, Xiaoyan Li, Xiance Tang   +5 more
doaj   +1 more source

What is the impact of psychiatric decision units on mental health crisis care pathways? Protocol for an interrupted time series analysis with a synthetic control study [PDF]

, 2020
Background The UK mental health system is stretched to breaking point. Individuals presenting with mental health problems wait longer at the ED than those presenting with physical concerns and finding a bed when needed is difficult – 91% of psychiatric ...
Anderson, K, Clarke, G, Gillard, S, Goldsmith, LP, Lomani, J, Smith, JG, Turner, K   +6 more
core   +3 more sources

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

The effect of the great Kermanshah earthquake on the tuberculosis infection trend: interrupted time series analysis

BMC Infectious Diseases
Objectives Tuberculosis (TB) presents a substantial danger to populations experiencing crises like earthquakes. This study aims to explore the effect of the Kermanshah earthquake on the trend of TB.
Ehsan Mardani-Talaee, Yahya Salimi, Fatemeh Heydarpour, Mitra Darbandi, Gholamreza Abdoli   +4 more
doaj   +1 more source

An interrupted time series analysis of the cardiovascular health benefits of a coal coking operation closure

Environmental Research: Health, 2023
With the widespread implementation of air pollution mitigation strategies for health and climate policy, there is an emerging interest in accountability studies to validate whether a reduction of air pollution exposure, in fact, produces the human health
Wuyue Yu, George D Thurston
doaj   +1 more source