Results 41 to 50 of about 17,641,379 (289)

The impact of policy interventions to promote the uptake of biosimilar medicines in Belgium: a nationwide interrupted time series analysis

Health Research Policy and Systems, 2023
Background The Belgian government has taken several measures to increase the uptake of biosimilars in past years. However, no formal evaluation of the impact of these measures has been made yet.
Yannick Vandenplas, Steven Simoens, Philippe Van Wilder, Arnold G. Vulto, Isabelle Huys   +4 more
doaj   +1 more source

Impact of Radiation Therapy on Physical and Psychosocial Health of Adolescents and Young Adults: A Joint Report From the Children's Oncology Group AYA and Radiation Oncology Committees

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Rates of cancer among adolescents and young adults (AYA), age 15–39 years, are increasing. Consequently, radiation oncologists are treating more AYAs who have diagnoses spanning both pediatric and adult practices. Compared to pediatric and older adult patients, AYAs face a unique set of challenges.
Hesham Elhalawani, Rachel K. Peterson, Avani D. Rao, Laurie J. McKenzie, Ahmed Magdy Elmotayam, Leslie Chang, Michael Roth, Susan L. McGovern   +7 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

The formulation of structural time series models in discrete and continuous time [PDF]

, 1983
This paper sets out an approach for modelling univariate time series, including those in which observations are available on a daily basis. An underlying continuous time model is formulated and it is shown that this model has important implications for ...
Harvey, A. C., Harvey, Andrew C.
core   +1 more source

Time series analysis of malaria cases to assess the impact of various interventions over the last three decades and forecasting malaria in India towards the 2030 elimination goals

Malaria Journal
Background Despite the progress made in this decade towards malaria elimination, it remains a significant public health concern in India and many other countries in South Asia and Asia Pacific region.
Mrigendra P. Singh, Harsh Rajvanshi, Praveen K. Bharti, Anup R. Anvikar, Altaf A. Lal   +4 more
doaj   +1 more source

Fiscal austerity and municipal health spending: an interrupted time series study [PDF]

Revista de Saúde Pública
OBJECTIVE To analyze the impact of the fiscal austerity policy (PAF) on health spending in Brazilian municipalities, considering population size and source of funds.
Leo Ramos Maia, Mônica Rodrigues Campos, Débora Castanheira   +2 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Context-Specific Impact Of Antimicrobial Stewardship On Antibiotic Use And Antibiotic Resistance In Hospitals In A Lower-Middle Income Country - Results From Implementation Study With A Controlled Interrupted Time Series Design In Vietnam

Journal of Global Antimicrobial Resistance
AIM: We aim to identify the impact of an antimicrobial stewardship (AMS) intervention, which includes pharmacist-led prospective audit with feedback, on hospital antibiotic use and resistance in two provincial-level general hospitals in Vietnam ...
Trang Quynh Le, Dung Tien Viet Vu, Quang Minh Le, Huyen Thi Thu Nguyen, Vinh Hai Vu, Duc Minh Chau, Em Thi Hoang Dung Vo, Tu Thi Cam Nguyen, Quan Anh Truong, Khanh Hong Nguyen, Hoa Nguyen Minh Le, Thomas Kesteman, Elizabeth Dodds Ashley, Deverick J. Anderson, Hugo C. Turner, Thach Ngoc Pham, Ben S. Cooper, Choisy Marc, H Rogier Van Doorn, Huong Thi Lan Vu   +19 more
doaj   +1 more source

Premature mortality due to cervical cancer: study of interrupted time series

Revista de Saúde Pública, 2020
OBJECTIVE: To verify the effect of the Pact for Health on premature mortality (30–69 years) attributed to cervical cancer in Brazil and its macroregions, using interrupted time series analysis. METHODS: Segmented regression was used to assess “change in
Maria Isabel do Nascimento, Felipe Corrêa Massahud, Nathália Giácomo Barbosa, Cássio Destefani Lopes, Vanessa da Costa Rodrigues   +4 more
doaj   +2 more sources