Results 121 to 130 of about 75,006 (300)

An Evaluation of the Impact of an OPEN Stewardship Generated Feedback Intervention on Antibiotic Prescribing among Primary Care Veterinarians in Canada and Israel

Animals
An interrupted time-series study design was implemented to evaluate the impact of antibiotic stewardship interventions on antibiotic prescribing among veterinarians.
Kamal R. Acharya, Adar Cohen, Gabrielle Brankston, Jean-Paul R. Soucy, Anette Hulth, Sonja Löfmark, John S. Brownstein, Nadav Davidovich, Moriah E. Ellen, David N. Fisman, Jacob Moran-Gilad, Amir Steinman, Derek R. MacFadden, Amy L. Greer   +13 more
doaj   +1 more source

Physician Incentives and Sex/Gender Differences in Depression Care: An Interrupted Time Series Analysis

Health Equity, 2020
Introduction: Physician incentives have been shown to reduce socioeconomic disparities in health care. The impact on sex/gender inequalities, however, has rarely been investigated.
doaj   +1 more source

A Toolkit for Targeted Neuromodulation of Striatal Direct Pathway Neurons Rescues Parkinsonian Motor Deficits in Mice

Advanced Science, EarlyView.
An adeno‐associated virus (AAV) toolkit enables selective anatomical and functional targeting of striatal D1‐MSNs through retrograde transduction. Enhanced capsids and engineered enhancers drive robust transgene expression across murine and primate models.
Zexuan Hong, Yujing Zhang, Junjiao Zhang, Hanhe Liu, Qiwei Liu, Yanglei Li, Lixin Yang, Lixia Li, Zhongjie Liu, Zhen Yuan, Zhonghua Lu, Yefei Chen, Yuantao Li, Yuwu Jiang, Taian Liu   +14 more
wiley   +1 more source

Impact of a new specialist alcohol and drug brief intervention service model integrated into the emergency department: An interrupted time series analysis

, 2020
To describe and examine the impact of a new specialist drug and alcohol brief intervention team (DABIT) model integrated into the ED on the identification of individuals at risk of future alcohol and other drug (AOD)-related harm. A cost-outcome analysis
Rachel A Elphinston, Alan Gude, Elphinston, Rachel A., Dominique De Andrade, Linda Hipper, Elphinston, Rachel A, Marianne Wyder, De Andrade, Dominique, Kim‐Huong Nguyen, Wyder, Marianne, Nguyen, Kim-Huong, Hipper, Linda, Gude, Alan   +12 more
core   +1 more source

Effect of flood on the cutaneous leishmaniasis incidence in northeast of Iran: an interrupted time series study

BMC Infectious Diseases
Introduction Cutaneous Leishmaniasis (CL) is a zoonosis infection which is endemic in more than 100 countries in Asia, Africa, Europe and America. It was estimated that nearly 20 thousand of new cases are reported in Iran annually.
Mostafa Majidnia, Atefeh Khoshkchali, Ahmad Khosravi   +2 more
doaj   +1 more source

A Microbial Lipid‐ATP Synthase Axis Fuels NK Cell Antitumor Activity

Advanced Science, EarlyView.
This study focuses on the mechanism by which gut microbiota‐derived outer membrane vesicles (OMVs) regulate NK cell antitumor activity. B. intestinalis is identified to decrease extra‐intestinal tumor growth via its OMVs enriched in sphingosine (SP).
Kaiyuan Yu, Xinyu Sun, Wanxia Ma, Jianming Yang, Xuan Sun, Lisong Zhang, Yumeng Liu, Tianshu Ren, Qi Wang, Jingyu Wang, Xiao Li, Xianping Peng, Liu Yang, Junqiang Lv, Zhi Yao, Zhi‐Song Zhang, Quan Wang   +16 more
wiley   +1 more source

Association Between Introduction of the 23-valent Pneumococcal Polysaccharide Vaccine (PPSV23) and Pneumonia Incidence and Mortality Among General Older Population in Japan: A Community-based Study

Journal of Epidemiology
Background: With global aging, especially in Asia, preventing pneumonia among seniors is vital. The necessity of introducing pneumococcal vaccines among the elderly has been highlighted, but there is a paucity of community-based real-world evidence on ...
Aya Sugiyama, Masaaki Kataoka, Kentaro Tokumo, Kanon Abe, Hirohito Imada, Bunlorn Sun, Golda Ataa Akuffo, Tomoyuki Akita, Shingo Fukuma, Noboru Hattori, Junko Tanaka   +10 more
doaj   +1 more source

β‐Elemene Rescues Radiation‐Induced Enteritis by Orchestrating a Host‐Microbiome Circuit That Fuels Epigenetic DNA Repair

Advanced Science, EarlyView.
This study elucidates that β‐elemene promotes cellular uptake of L. gasseri‐derived lactate by enhancing the membrane translocation of MCT1 in a CD147‐dependent manner. Intracellular lactate, through the lactylation of RBBP4 at the K26 site, recruits EP300 to the promoter regions of downstream genes (POLD1/POLD3), catalyzing H3K27ac modification.
Jiancheng He, Jiapeng Bao, Shukang Deng, Weijie Zang, Haoming Yan, Zihao Zhao, Guangze Zhang, Ruiqing Liu, Junjie Chen, Yilin Hu, Wanjiang Xue   +10 more
wiley   +1 more source

Pneumococcal meningitis trends after pneumococcal conjugate vaccine introduction in Colombia: An interrupted time-series analysis

, 2018
Colombia introduced mass pneumococcal conjugate vaccination at the end of 2011. Using 2005–2015 surveillance data, we conducted a retrospective interrupted time-series analysis.
Diana C. Caceres, Rodrigo DeAntonio, Javier Nieto, Eduardo Ortega-Barria   +3 more
core   +1 more source

Interrupted time series datasets from studies investigating the impact of interventions or exposures in public health and social science: a data note

BMC Research Notes
Objectives The interrupted time series (ITS) design is commonly used to investigate the impact of an intervention or exposure in public health. There are many statistical methods that can be used to analyse ITS data and to meta-analyse their results.
Simon L Turner, Elizabeth Korevaar, Amalia Karahalios, Andrew B Forbes, Joanne E McKenzie   +4 more
doaj   +1 more source