Results 31 to 40 of about 741,333 (292)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Mathematic Lesson Design for English Learners Versus Non-English Learners From Perspectives of Equity and Intersection

Journal of Urban Mathematics Education, 2022
Calls for “mathematics for all” or “mathematics for social justice” bring light to the importance of equity issues within and through mathematics education.
Seonhee Cho
doaj  

Bayesian designs for hierarchical linear models [PDF]

, 2012
Two Bayesian optimal design criteria for hierarchical linear models are discussed – the ?? criterion for the estimation of individual-level parameters ?, and the ?? criterion for the estimation of hyperparameters ?.
Allenby, Gregory, Qing Liu, Dean, Angela, Liu, Qing, Angela M. Dean, Greg M. Allenby   +5 more
core   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Convex Cone Conditions on the Structure of Designs [PDF]

, 2003
Various known and original inequalities concerning the structure of combinatorial designs are established using polyhedral cones generated by incidence matrices. This work begins by giving definitions and elementary facts concerning t-designs.
Dukes, Peter James
core   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Alabama road map and directory, Tempo Designs, Chicago, Illinois 1975-76

, 1975
The digitization of this collection was funded by a gift from EBSCO ...
Tempo Designs
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Intersectional Feminism: A Primer [PDF]

English Description: This primer introduces the concept of intersectional feminism and serves as a guiding document for Oxfam America staff.
Molano, Sebastián, Castro Bernardini, María del Rosario, Castellanos, Paige, Jayasinghe, Namalie, Kellogg, Molly   +4 more
core   +1 more source