Results 41 to 50 of about 741,333 (292)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Maximin optimal designs for a compartmental model [PDF]

, 2004
For an important example from the class of compartmental models we determine optimal designs, which are robust against misspecifications of the unknown model parameters.
Stefanie Biedermann, Andrey Pepelyshev, Dette, Holger, H. Dette, Holger Dette, Pepelyshev, Andrey, S. Biedermann, Biedermann, Stefanie, A. Pepelyshev   +8 more
core   +2 more sources

Centering transgender and gender nonconforming people of color in the study of minority stress, transition-related factors, and mental health

Frontiers in Public Health
BackgroundTransgender and gender non-conforming individuals (TGNC) people of color (POC) are exposed to a unique intersection of gender and racial-minority stressors.
Michelle R. Dalton, Scott Secrest, Aline Araujo Hoffmann, Maria Nash, Divya Patel, Joanne Salas, M. Paz Galupo, Katie Heiden-Rootes   +7 more
doaj   +1 more source

Precarious employment in occupational health – an OMEGA-NET working group position paper

Scandinavian Journal of Work, Environment & Health, 2020
OBJECTIVES: The aims of this position paper are to (i) summarize research on precarious employment (PE) in the context of occupational health; (ii) develop a theoretical framework that distinguishes PE from related concepts and delineates important ...
Theo Bodin, Çiğdem Çağlayan, Anne Helene Garde, Marco Gnesi, Johanna Jonsson, Sibel Kiran, Bertina Kreshpaj, Taina Leinonen, Ingrid Sivesind Mehlum, Evangelia Nena, Cecilia Orellana, Trevor Peckham, Noah Seixas, Christophe Vanroelen, Mireia Julià   +14 more
doaj   +1 more source

Block intersections in quasi-residual designs

Aequationes Mathematicae, 1970
A quasi-residual design is defined in [8] as a BIBD having the parameters of a residual design. The main problem concerning these designs lies in answering the question "Is a quasi-residual design necessarily a residual design?" For 2 = 1 or 2 it has been shown that all quasi-residual designs are also residual designs (Connor and Hall [3]), but a ...
openaire   +2 more sources

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

HInter: Exposing Hidden Intersectional Bias in Large Language Models [PDF]

Large Language Models (LLMs) may portray discrimination towards certain individuals, especially those characterized by multiple attributes (aka intersectional bias). Discovering intersectional bias in LLMs is challenging, as it involves complex inputs
Yokoyama, Setsuko, Chattopadhyay, Sudipta, PAPADAKIS, Mike, Le Traon, Yves, SOREMEKUN, Ezekiel, SOUANI, Badr   +5 more
core   +1 more source

A Note on t-designs with t Intersection Numbers [PDF]

Discrete Mathematics & Theoretical Computer Science, 2004
We discuss Ray-Chaudhari and Wilson inequality for a 0-design and give simple proof of the result '\emphFor fixed block size k, there exist finitely many parametrically feasible t-designs with t intersection numbers and λ > 1'.
openaire   +7 more sources

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source