Results 271 to 280 of about 526,517 (342)
Advanced Science, EarlyView.NEU1, a key regulator of glycolysis, is markedly upregulated following DOX treatment. This upregulation is attributed to HIF1α’s transcriptional repression, requiring intricate interactions with NRF2. Increased NEU1 facilitates SIRT1 lysosomal degradation, contributing to aberrant glycolytic phenotype and cardiac damage.
Ting Gao +13 more
wiley +1 more source
Biosecurity Primitive: Polymerase X‐based Genetic Physical Unclonable Functions
Advanced Science, EarlyView.What if every cell line can carry an unforgeable genomic fingerprint—one that proves its origin, ensures its authenticity, and thwarts unauthorized duplication? Here, CRISPR‐induced DNA lesions paired with TdT‐mediated repair produce robust, unique, and unclonable genetic signatures—advancing the concept of molecular Physical Unclonable Functions (PUF)
Zikun Zhou +7 more
wiley +1 more source
Advanced Science, EarlyView.Stepwise excitation of dual‐color responsive molecules in a novel intersecting half‐cone geometry provides excellent spatial resolution while retaining the high efficiency and thus speed of the overall process. The approach provides volumetric methods with an enhanced performance at the nanoscale.
Martin Regehly, Stefan Hecht
wiley +1 more source
Advanced Science, EarlyView.This article investigates the multi‐factor optimization of nickel foam flow fields in PEMFCs, focusing on compression, porosity, pore size, hydrophobicity, and surface coatings. Through comprehensive experiments and analysis, it reveals how structural and surface modifications influence electrochemical performance, water management, and corrosion ...
Siyuan Wu +5 more
wiley +1 more source
From Code to Life: The AI‐Driven Revolution in Genome Editing
Advanced Science, EarlyView.This review explores AI‐driven advancements in genome editing, focusing on CRISPR optimization, enhanced targeting precision, reduced off‐target effects, and novel tool design. It addresses ethical challenges, data biases, and highlights future prospects in precision medicine, agriculture, and synthetic biology.
Zhidong Li +10 more
wiley +1 more source
Advanced Science, EarlyView.p‐n type carbon quantum dots (N‐CQDs) are designed as a conceptually‐new “semiconductor electrolyte” to develop a self‐driven photoelectrochemical cell that can be switched to optimize between H2O2 production and electricity generation under visible‐light illumination with water and O2 as reaction reagents.
Hui‐Min Duan +8 more
wiley +1 more source
Advanced Science, EarlyView.This review compares clinical outcomes, translational progress, and global funding trends across cancer phototherapies—photodynamic, photothermal, and photoimmunotherapy—and conventional immunotherapy. It highlights differences in treatment efficacy, clinical trial status, financial investment, and regulatory challenges, providing a comprehensive ...
Deepak S. Chauhan +6 more
wiley +1 more source
Advanced Science, EarlyView.A novel nanolayered manganese oxide material (Na‐NLMO) is prepared using a rapid and straightforward method for efficient adsorption of Sr(II) in both simulated waste liquid and natural water systems. Its excellent adsorption performance of Na‐NLMO could be attributed to the accessible layered structure and negatively charged framework.
Fan Wang +13 more
wiley +1 more source