Results 41 to 50 of about 132,124 (298)

A Tri‐Culture Heart‐on‐a‐Chip Platform With iPSC‐Derived Cardiac Cells for Predictive Cardiotoxicity Testing

Advanced Healthcare Materials, EarlyView.
This study presents the first entirely isogenic heart‐on‐chip, unifying cardiomyocytes, fibroblasts, and endothelial cells from a single iPSC source. The platform reveals a critical biological insight: the endothelium actively shields cardiac tissue from drug‐induced toxicity, challenging the predictive accuracy of conventional, avascular models for ...
Karine Tadevosyan, Jose Yeste, Mar Alvarez, Denise Marrero, Laura Casado‐Medina, Yvonne Richaud‐Patin, Olalla García‐Iglesias, Jagoda Litowczenko, Alba Morillas Garcia, Anton Guimerà, Xavi Illa, Rosa Villa, Angel Raya   +12 more
wiley   +1 more source

Cross-species variability in lobular geometry and cytochrome P450 hepatic zonation: insights into CYP1A2, CYP2D6, CYP2E1 and CYP3A4

Frontiers in Pharmacology
There is a lack of systematic research exploring cross-species variation in liver lobular geometry and zonation patterns of critical drug-metabolizing enzymes, a knowledge gap essential for translational studies.
Mohamed Albadry, Mohamed Albadry, Jonas Küttner, Jonas Küttner, Jan Grzegorzewski, Olaf Dirsch, Eva Kindler, Robert Klopfleisch, Vaclav Liska, Vaclav Liska, Vladimira Moulisova, Sandra Nickel, Richard Palek, Richard Palek, Jachym Rosendorf, Jachym Rosendorf, Sylvia Saalfeld, Utz Settmacher, Hans-Michael Tautenhahn, Hans-Michael Tautenhahn, Matthias König, Uta Dahmen   +21 more
doaj   +1 more source

An effective-field-theory analysis of Efimov physics in heteronuclear mixtures of ultracold atomic gases

, 2016
We use an effective-field-theory framework to analyze the Efimov effect in heteronuclear three-body systems consisting of two species of atoms with a large interspecies scattering length.
Acharya, Bijaya, Ji, Chen, Platter, Lucas   +2 more
core   +1 more source

Respiratory Organ‐on‐a‐Chip for Disease Modeling: From Architecture to Functional Integration

Advanced Healthcare Materials, EarlyView.
Respiratory organ‐on‐a‐chip (ROC) models capture key mechanical and cellular cues of the human respiratory system, enabling quantitative dissection of disease mechanisms. This review links ROC architectures to disease modeling, functional integration, and commercialization, and proposes a decision framework that aligns model complexity with mechanistic
Jinzhuo Hu, Yongjie Tang, Sidi Liu, Tao Xu, Qian Liu   +4 more
wiley   +1 more source

Older Humans and Their Dogs

Humanimalia
Loneliness and a lack of socialization can have a deteriorating effect on life experience and health. Unfortunately, loneliness is an experience often felt by older people, and interspecies companionship can provide valuable and daily interaction that ...
Angela Bartram
doaj   +1 more source

Dynamics of a two-species Bose-Einstein condensate in a double well

, 2009
We study the dynamics of a two-species Bose-Einstein condensate in a double well. Such a system is characterized by the intraspecies and interspecies s-wave scattering as well as the Josephson tunneling between the two wells and the population transfer ...
Pindzola, M. S., Sun, B.
core   +1 more source

A two species trap for chromium and rubidium atoms [PDF]

, 2004
We realize a combined trap for bosonic chromium 52Cr and rubidium 87Rb atoms. First experiments focus on exploring a suitable loading scheme for the combined trap and on studies of new trap loss mechanisms originating from simultaneous trapping of two ...
Axel Griesmaier, Axel Görlitz, Jörg Werner, Pu H., Stuhler J., Sven Hensler, Tilman Pfau   +6 more
core   +2 more sources

A Physiological Microfluidic Blood–Brain‐Barrier Model for In Vitro Study of Nanoparticle Trafficking and Accumulation

Advanced Healthcare Materials, EarlyView.
A human microfluidic blood‐brain barrier (mBBB) model enables spatially resolved comparison of nanoparticle trafficking. Extracellular vesicles (EVs), liposomes, and nanoplastics exhibit distinct transport and disruption behaviors, revealing that membrane composition and uptake pathways govern BBB interaction.
Bryan B. Nguyen, Neona M. Lowe, Sophia Kellogg, Kuan‐Wei Huang, Hannah O'Toole, Elizabeth J. Hale, Venktesh S. Shirure, Bhupinder S. Shergill, Steven C. George, Randy P. Carney   +9 more
wiley   +1 more source

Retrospective Analysis of Archived Pyrazinamide Resistant Mycobacterium tuberculosis Complex Isolates from Uganda—Evidence of Interspecies Transmission

Microorganisms, 2019
The contribution of Mycobacterium bovis to the proportion of tuberculosis cases in humans is unknown. A retrospective study was undertaken on archived Mycobacterium tuberculosis complex (MTBC) isolates from a reference laboratory in Uganda to identify ...
Sylvia I. Wanzala, Jesca Nakavuma, Dominic Travis, Praiscillia Kia, Sam Ogwang, Wade Ray Waters, Tyler Thacker, Timothy Johnson, Syeda Anum Hadi, Srinand Sreevatsan   +9 more
doaj   +1 more source

A distinguishable single excited-impurity in a Bose-Einstein condensate

, 2018
We investigate the properties of a distinguishable single excited state impurity pinned in the center of a trapped Bose-Einstein condensate (BEC) in a one-dimensional harmonic trapping potential by changing the bare mass of the impurity and its ...
Akram, Javed
core   +1 more source