Results 71 to 80 of about 22,613 (244)

Multimodal AI‐Driven Identification of Dehydrocostus Lactone as a Potent Renal Fibrosis Attenuator Targeting IQGAP1

Advanced Science, EarlyView.
Renal fibrosis, a hallmark of CKD, lacks effective treatments. Herein, we developed a multimodal AI model (TCM‐SPred) to identify anti‐fibrotic agents and found that dehydrocostus lactone (DCL) targets IQGAP1 to inhibit Wnt signaling, blocking the interaction between IQGAP1 and CCT3, demonstrating potent anti‐fibrotic activity in vitro and in vivo ...
Weijiang Lin, Wenzhuo Xu, Kang Liu, Ping Wang, Zhenzhen Zhu, Wenyu Lu, Zhe Zheng, Xiaoqian Peng, Xunkai Yin, Shulan Mei, An Pan, Jian Liu, Lihong Hu   +12 more
wiley   +1 more source

Case Report: Agonistic interaction between Amazonian manatee (Trichechus inunguis) and Tucuxi dolphins (Sotalia fluviatilis) in Brazil

Frontiers in Ethology
BackgroundInterspecific interactions play an important role in shaping ecological relationships, yet descriptions of social interspecific interactions in aquatic mammals remain scarce.
Layse Albuquerque, Layse Albuquerque, Layse Albuquerque, Karen Lucchini, Karen Lucchini, Karen Lucchini, Matheus L. Soares, Daniel L. Z. Kantek, Fernanda L. N. Attademo, Fernanda L. N. Attademo, Bruna Bezerra, Bruna Bezerra, Fábia O. Luna   +12 more
doaj   +1 more source

Profiling Localized Immunomodulation and Drug Biodistribution within a Subcutaneous Vascularized Niche for Cell Transplantation

Advanced Science, EarlyView.
We studied how five common immunosuppressants behave when delivered directly to a transplant site instead of systemically. Using a vascularized implant for islet transplantation, we show that local delivery protects grafts, limits drug spread to the rest of the body, and produces distinct immune signatures.
Jocelyn Nikita Campa‐Carranza, Simone Capuani, Melissa A. Willman, Alexander Rabassa, Ashley L. Joubert, Tommaso Bo, Letizia Franco, Marzia Conte, Ana L. Anaya‐García, Gabrielle E. Rome, Rim Ouni, Henry J. Seaborne, Camden A. Caffey, Dora M. Berman, Junjun Zheng, Jesus Paez‐Mayorga, Corrine Ying Xuan Chua, Shu Hsia Chen, Norma S. Kenyon, Alessandro Grattoni   +19 more
wiley   +1 more source

Inferring Bacterial Interspecific Interactions from Microcolony Growth Expansion

microLife
AbstractInteractions between species are thought to be crucial for modulating their growth and behaviour within communities, and determinant for the emergence of community functions. Several different interaction concepts exist, but there is no consensus on how interactions should be quantified and integrated in community growth theory.
Tania Miguel Trabajo, Isaline Guex, Manupriyam Dubey, Elvire Sarton-Lohéac, Helena Todorov, Xavier Richard, Christian Mazza, Jan Roelof van der Meer   +7 more
openaire   +3 more sources

Extracellular Vesicles in Autoimmune Diseases: From Diagnostic Biomarkers to Engineered Therapeutics

Advanced Science, EarlyView.
This review provides a systematic comparison of extracellular vesicles (EVs) from both mammalian and plant sources in the context of autoimmune diseases. It highlights their emerging roles as precision biomarkers and engineered therapeutic platforms.
Yufei Wu, Huiyuan Ma, Tinghui Zhu, Shuwei Huang, Manxi Lu, Qiong Wang, Zai‐Long Chi   +6 more
wiley   +1 more source

Integrating Human Intestinal Organoids into FDA'S New Approach Methodologies for Drug Discovery

Advanced Science, EarlyView.
Illustration summarizes how human intestinal organoids (HIOs) are becoming transformative in preclinical research. Preclinical drug discovery pipelines often rely on animal models for ADMET studies, even though interspecies ADME gaps, poor external validity, and high attrition rates are common.
Debarun Patra, Ibrahim M. Sayed, Souhrid Mukherjee, Honit Piplani, Aida Habtezion, Michael J. Rosen, Jospeh C. Wu   +6 more
wiley   +1 more source

Temperature sensitivity of the interspecific interaction strength of coastal marine fish communities. [PDF]

Elife, 2023
Ushio M, Sado T, Fukuchi T, Sasano S, Masuda R, Osada Y, Miya M.   +6 more
europepmc   +1 more source

Development‐based In Vivo Bioreactor Strategy for Challenging Senescent Bone Reconstruction

Advanced Science, EarlyView.
We present a development‐based in vivo bioreactor strategy to generate rejuvenated bone grafts (vBR‐Bone) within aged hosts. By enclosing vBR‐Bone fragments within an asymmetric biomimetic periosteum, segmental femoral defects in aged mice were successfully repaired within 6 weeks. Mechanistically, the multifactors of vBR‐Bone reconstitute a remodeling
Wenchao Zhang, Kai Dai, Tong Shen, Zehua Gao, Fengying Yan, Yuke Feng, Xuanlin Wang, Shaozhen Zhang, Jing Wang, Changsheng Liu   +9 more
wiley   +1 more source

Effects of Green Manure Intercropping on Soil Moisture, Nutrients, and Apple Yield in a Weibei Apple Orchard

Shuitu Baochi Xuebao
［Objective］ We conducted a field experiment to investigate the effects of intercropping green manure crops and their combination with ground fabric mulching on soil moisture, fertility, and apple yield.
LIANG Qing, ZHANG Tibin, CHENG Yu, GAO Weiqiang, KUANG Yuxin, FENG Hao   +5 more
doaj   +1 more source

Weed Suppression in Only-Legume Cover Crop Mixtures

Agronomy, 2019
Weed suppression is a potential benefit of cover crop mixtures, as species diversity may allow for combining early and late-season competition with weeds.
Heba Elsalahy, Thomas Döring, Sonoko Bellingrath-Kimura, Danny Arends   +3 more
doaj   +1 more source