Results 171 to 180 of about 46,210 (213)

Lost and found in translation: the value of the human imiquimod model

British Journal of Clinical Pharmacology, EarlyView.
Topical imiquimod (IMQ), a Toll‐like receptor (TLR) 7 agonist, induces transient cutaneous inflammation and is widely used in preclinical research as a ‘psoriasis‐like’ mouse model. However, accumulating evidence indicates substantial divergence between IMQ‐driven biology and human plaque psoriasis pathogenesis.
Anouk C. Meijs, Juliette A. van den Noort, Salma Assil, Naomi B. Klarenbeek, Matthijs Moerland, Tessa Niemeyer‐van der Kolk, Robert Rissmann   +6 more
wiley   +1 more source

The integrated Lei‐CNS PBPK‐PD model effectively predicts clozapine brain disposition and D2 receptor occupancy in humans

British Journal of Clinical Pharmacology, EarlyView.
Aim Clozapine, used for treatment‐resistant schizophrenia, has a narrow therapeutic window and highly variable plasma pharmacokinetics (PK), necessitating careful monitoring. Direct measurement of unbound brain PK in humans is unethical. To develop a physiologically based pharmacokinetic–pharmacodynamic (PBPK‐PD) model to predict clozapine brain ...
Mengxu Zhang, Thomas I. F. H. Cremers, Vivi Rottschäfer, Elizabeth C. M. de Lange   +3 more
wiley   +1 more source

Species Dynamics and Gene Expression in Algal Polycultures Under Mixotrophic Cultivation in Outdoor Pilot‐Scale Nordic Conditions

Biotechnology and Bioengineering, EarlyView.
These results demonstrate that mixotrophic conditions drive both microbial community shifts and metabolic reprogramming, underscoring the importance of cultivation strategy and polyculture selection for targeted applications such as nutrient recovery and bioproduct generation.
Quyen Nham, Hanna Farnelid, Catherine Legrand, Elin Lindehoff   +3 more
wiley   +1 more source

Induction and Enhancement of Bacteriocin Production (Review)

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Conventionally, bacteriocins are produced by microorganisms on complex substrates, released as semi‐purified preparations or crude fermentates. These bacteriocin‐containing products often exhibit unsatisfactory purity, low active‐substance content, and high production costs, limiting their commercialization and use. This review aims to analyze
Oksana Knysh, Artur Martynov
wiley   +1 more source

Beyond antimicrobials: Ecological nano‐strategies for rebalancing dysbiotic oral microbial homeostasis

BMEMat, EarlyView.
Oral microbial homeostasis, a dynamic host‐microbe balance, is vital in infectious diseases. Conventional antibiotics often disrupt this homeostasis, spurring interest in nanomaterials for oral microbial homeostasis rebalancing. This review outlines nanomaterial strategies across three ecological levels (population/community, ecosystem, and cross ...
Chen Hu, Aohan Luan, Yujun Yang, Linlin Wang, Huilin Wang, Ning Wang, Guixin He, Yajie Yang, Rabiya Noor, Jawad Hussain, Longquan Shao   +10 more
wiley   +1 more source

Interspecific variation in the limb long bones among modern rhinoceroses-extent and drivers. [PDF]

PeerJ, 2019
Mallet C, Cornette R, Billet G, Houssaye A.   +3 more
europepmc   +1 more source

Ant Diversity of the Xisha Islands: Community Structure, Exotic Species Colonization, and Ecological Functions in a Tropical Coral Archipelago

Biological Diversity, EarlyView.
The first inventory of ants from the Xisha Islands of the South China Sea was compiled, revealing 21 species: 70% native and 30% exotic. Anthropogenic disturbance primarily drove exotic colonization, whereas island area showed weak positive effects on species richness. Most ants were omnivorous, with key mutualistic and seed‐dispersal roles.
Hua‐Yan Chen, Zhi‐Xuan Liu, Zheng‐Hui Xu, Rui‐Chong Wang, Shi‐Xiao Luo   +4 more
wiley   +1 more source

Life Forms and Mycorrhizal Types Shape Resource‐Use Strategies Reflected by Different Functional Traits in Woody Plants of the Qinling Mountains

Biological Diversity, EarlyView.
Both life forms and mycorrhizal symbioses shape plant functional trait divergence, revealing divergent resource‐use strategies across woody species in temperate forests. ABSTRACT Plant functional traits are influenced by both mycorrhizal types and life forms, yet the interactive effects of these two factors on functional trait regulation remain poorly ...
Bingxiang Xue, Meiping Gao, Na Liu, Ranran Cheng, Lishunan Yang, Zihan Zhou, Chunmei He, Xiaochao Yang, Shihong Jia, Zuoqiang Yuan, Zhanqing Hao, Qiulong Yin   +11 more
wiley   +1 more source

Interspecific variation of olfactory preferences in flies, mice, and humans. [PDF]

Chem Senses, 2019
Manoel D, Makhlouf M, Scialdone A, Saraiva LR.   +3 more
europepmc   +1 more source

Dynamics of biotic resistance to plant invasions

Biological Reviews, EarlyView.
ABSTRACT Biotic resistance, the reduction in invasion success caused by native communities, plays an important role in the long‐term dynamics of biological invasions. A large body of empirical research on biotic resistance has accumulated since the last comprehensive review on the subject 20 years ago, enabling us to achieve a refined understanding of ...
Christine S. Sheppard, Joshua I. Brian, Wayne Dawson, Petr Dostál, Franz Essl, Michal Gruntman, Tina Heger, Mark van Kleunen, Mialy Razanajatovo, Lena C. Reimann, Frank M. Schurr, Montserrat Vilà, Florencia A. Yannelli, Marina Golivets   +13 more
wiley   +1 more source