Results 191 to 200 of about 46,210 (213)

Special Populations in Pivotal Clinical Trials: Eligibility and Supporting Evidence for Exclusion in EMA‐Authorised Medicines

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Evidence on the efficacy and safety of medicines supporting marketing authorization is largely derived from randomized controlled trials, yet these trials often exclude populations likely to use the medications in clinical practice. This study assessed eligibility of special populations, defined as pregnant and breast‐feeding individuals, elderly ...
Maja J. Jørgensen   +2 more
wiley   +1 more source

Differential sensitivity to SHH signaling and neural crest‐mediated Gas1 expression regulate jaw size during development and evolution

open access: yesDevelopmental Dynamics, EarlyView.
Abstract Background Developmental control of jaw size is crucial to prevent birth defects and facilitate evolutionary adaptation. We have shown that jaw size is established by neural crest mesenchyme (NCM), which are progenitor cells that migrate into the mandibular primordia and produce the jaws.
Zuzana Vavrušová   +5 more
wiley   +1 more source

Spatial variation in liana effects on host‐tree allometry and biomass in an intact tropical forest

open access: yesEcography, EarlyView.
Lianas are increasing in abundance across the tropics, yet local spatial variation in their effects on host‐tree allometry and biomass, and the drivers of this variation within forests, remain poorly understood. Using field inventory, drone photogrammetry, and terrestrial laser scanning (TLS) across a 50‐ha plot on Barro Colorado Island, Panama, we ...
Sruthi M. Krishna Moorthy   +9 more
wiley   +1 more source

Taxon‐dependent multisite species turnover in fragmented habitats: comparing zeta diversity across birds, butterflies, and cursorial hunting spiders

open access: yesEcography, EarlyView.
Habitat fragmentation alters species diversity and reshapes community composition. However, conventional pairwise approaches to compositional variation (i.e. beta diversity metrics) do not explicitly characterize how species sharing or turnover change with the number of habitat patches.
Shirui Yu   +11 more
wiley   +1 more source

Climatic thresholds and temporal decoupling drive reproductive phenology in Neotropical cloud forests: a 36‐year analysis

open access: yesEcography, EarlyView.
Reproductive phenology influences ecosystem functioning and climate sensitivity in tropical montane cloud forests, but phase‑specific climatic thresholds and the temporal coupling between flowering and fruiting remain poorly quantified over decadal scales. We analyzed a 36‑year monthly record (1983–2018) from a Venezuelan cloud forest (15 focal species)
Saúl Flores   +2 more
wiley   +1 more source

Spatial variation and predictors of plant species' intrinsic climate sensitivity across the conterminous United States

open access: yesEcography, EarlyView.
Understanding how species' sensitivity to climate varies spatially across their ranges and elucidating the important causes is essential for identifying ecologically meaningful geographic units and conservation actions for biodiversity. In this study, we estimated climatic occurrence niches of vascular plants to explore the spatial variation in species'
Weiqing Qu   +4 more
wiley   +1 more source
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Worldwide Variations in Colorectal Cancer

Ca-A Cancer Journal for Clinicians, 2009
Ahmedin Jemal, Robert A Smith, E Ward
exaly  

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